| 100% | UHOH | 4 | "Looks like we have a problem!": Hyph. |
| 65% | UHOH | 4 | "We have a problem here": Hyph. |
| 64% | UHOH | 4 | "This looks like a problem": Hyph. |
| 62% | UHOH | 4 | "We may have a problem here": Hyph. |
| 60% | UHOH | 4 | "Houston, we have a problem ..." |
| 59% | NASA | 4 | "Houston, we have a problem" grp. |
| 59% | HOUSTON | 7 | Paraphrasing Swigert, "__, we have a problem" |
| 59% | UHOH | 4 | “Er, we have a problem here ...” |
| 59% | NASA | 4 | "Houston, we have a problem" organisation: Abbr. |
| 56% | THERESONEHITCH | 14 | ''Except, we have a little problem . . .'' |
| 50% | MOTH | 4 | Insect that looks like a butterfly and has a "Gothic" species |
| 49% | HOUSTON | 7 | NASA city from the "we have a problem" saying |
| 49% | LETMESEE | 8 | "I'd like to have a look" |
| 49% | AHA | 3 | First Norwegian band to have a #1 hit in the US: Hyph. |
| 49% | SOS | 3 | Brand name that looks like it has a missing period |
| 49% | UHOH | 4 | "Looks like we've got trouble": Hyph. |
| 49% | UHOH | 4 | "Looks like we're in trouble": Hyph. |
| 49% | UHOH | 4 | "Looks like we're in trouble!": Hyph. |
| 48% | HUT | 3 | Pizza ___ (chain whose logo has a red roof that looks like a hat) |
| 48% | VET | 3 | Kind of doc who'd have a look at Scooby Doo's problems |
| 48% | NASA | 4 | "Houston, we've had a problem here" org. |
| 47% | PRUNE | 5 | Fruit that looks like a finger that has soaked in a bath for too long |
| 47% | MIND | 4 | Have a problem with |
| 47% | MINDED | 6 | Had a problem with |
| 47% | MINDS | 5 | Has a problem with |
| 45% | WELLWELLWELL | 12 | "Just look what we have here...," and a summary of 20-, 28- and 46-Across |
| 45% | SKIDS | 5 | Has a problem on the road |
| 44% | RENEGED | 7 | Had a problem with one's suits? |
| 44% | SEE | 3 | Have a look |
| 44% | EYE | 3 | Have a look |