| 100% | EVANOBLEZADA | 12 | "Luck" voice actress who plays Ruth in 44-Across (2 wds.) |
| 64% | LETITIAWRIGHT | 13 | "Ready Player One" actress who plays Shuri in 44-Across (2 wds.) |
| 64% | BRIELARSON | 10 | "Room" actress who plays 44-Across in "Captain Marvel" (2 wds.) |
| 64% | FRANCESFISHER | 13 | Actress who played Ruth DeWitt Bukater, Rose's widowed mother in the movie "Titanic": 2 wds. |
| 64% | FELICITYJONES | 13 | Actress who played Ruth Bader Ginsburg in the film "On the Basis of Sex": 2 wds. |
| 63% | AMYBRENNEMAN | 12 | Former "NYPD Blue" actress who plays Laurie Garvey in 44-Across: 2 wds. |
| 62% | CLORISLEACHMAN | 14 | "Raising Hope" actress who played Ruth Popper in 1971's "The Last Picture Show": 2 wds. |
| 62% | TIFFANYHADDISH | 14 | "The Freak Brothers" voice actress who plays Vanessa on 44-Across (2 wds.) |
| 62% | LUPITANYONGO | 12 | "12 Years a Slave" actress who plays Nakia in 44-Across (2 wds.) |
| 62% | RACHELMCADAMS | 13 | "Spotlight" actress who played Allie Hamilton in 44-Across (2 wds.) |
| 60% | MCKENNAGRACE | 12 | "The Haunting of Hill House" actress who plays young 44-Across in "Captain Marvel" (2 wds.) |
| 60% | MAYARUDOLPH | 11 | "Bridesmaids" actress who plays Christine in 32-Across: 2 wds. |
| 59% | MIREILLEENOS | 12 | "The Killing" actress who plays Marissa in 33-Across: 2 wds. |
| 59% | CRISTINMILIOTI | 14 | Actress who plays a wedding guest who's stuck in a time loop in 44-Across: 2 wds. |
| 59% | ELLENBARKIN | 11 | "Sea of Love" actress who plays Smurf Cody in 44-Across (2 wds.) |
| 59% | ELLIEKEMPER | 11 | Actress who plays the lead role in 12-/24-Across: 2 wds. |
| 59% | RACHELZEGLER | 12 | Actress who plays Maria in 30-Across (2 wds.) |
| 59% | ARIANADEBOSE | 12 | Actress who plays Anita in 30-Across (2 wds.) |
| 58% | FELICITYJONES | 13 | "Rogue One" actress who plays Ruth Bader Ginsburg in "On the Basis of Sex" (2 wds.) |
| 58% | JULIANNEMOORE | 13 | "Still Alice" actress who plays 19-Across later in life: 2 wds. |
| 58% | SANDRADEE | 9 | Actress who played Gidget in 1959: 2 wds. |
| 57% | BETTEMIDLER | 11 | "Beaches" actress who played witch Winnie Sanderson in 29-/30-Across: 2 wds. |
| 57% | ANYATAYLORJOY | 13 | "Glass" actress who played 19-Across in a 2020 film: 2 wds., hyph. |
| 57% | SISSYSPACEK | 11 | "Carrie" actress who plays Ruth Deaver on "Castle Rock": 2 wds. |
| 57% | FRANDRESCHER | 12 | "Hotel Transylvania" voice actress who plays a beauty school teacher in "The Beautician and the Beast" (2 wds.) |
| 57% | CAMILACABELLO | 13 | "Trolls Band Together" voice actress who played the title role in the 2021 movie musical "Cinderella" (2 wds.) |
| 57% | LEAMICHELE | 10 | Actress who plays 17-Across' girlfriend and was 29-Across' girlfriend in real life: 2 wds. |
| 57% | KATHYNAJIMY | 11 | "Sister Act" actress who played witch Mary Sanderson in 29-/30-Across: 2 wds. |
| 57% | JENNIFERLOPEZ | 13 | "Hustlers" actress who played US marshal Karen Sisco in 23-/35-Across: 2 wds. |
| 57% | JACKIWEAVER | 11 | "Silver Linings Playbook" actress who plays Sandy in 32-Across: 2 wds. |