| 100% | ELISABETHMOSS | 13 | "Mad Men" actress who plays Ofglen in "The Handmaid's Tale" (2 wds.) |
| 92% | ELISABETHMOSS | 13 | "Mad Men" actress who plays Offred in "The Handmaid's Tale": 2 wds. |
| 72% | SAMIRAWILEY | 11 | "Orange Is the New Black" actress who plays Moira in "The Handmaid's Tale" (2 wds.) |
| 69% | ELISABETHMOSS | 13 | "The Handmaid's Tale" actress who plays the writer Shirley Jackson in "Shirley" (2 wds.) |
| 69% | MCKENNAGRACE | 12 | "The Handmaid's Tale" actress who plays Phoebe Spengler in "Ghostbusters: Frozen Empire": 2 wds. |
| 68% | ELISABETHMOSS | 13 | "Mad Men" actress who plays June Osborne on "The Handmaid's Tale" (2 wds.) |
| 67% | ALEXIS | 6 | With 34-Across, "Gilmore Girls" actress who plays Ofglen in "The Handmaid's Tale" |
| 65% | MCKENNAGRACE | 12 | "The Handmaid's Tale" actress who plays Phoebe Spengler in 3-Down/4-Down (2 wds.) |
| 62% | ELISABETHMOSS | 13 | Golden Globe-winning "The Handmaid's Tale" actress who plays Masha in the 2018 film "The Seagull" (2 wds.) |
| 61% | GEMMAARTERTON | 13 | "Quantum of Solace" actress who plays Polly in "The King's Man": 2 wds. |
| 61% | HALLEBERRY | 10 | "X-Men" actress who played Catwoman in the 2004 movie "Catwoman": 2 wds. |
| 61% | LAURADERN | 9 | Actress who plays Jennifer Fox in "The Tale" and has an Outstanding Lead Actress nomination for the 70th Emmys: 2 wds. |
| 61% | ELISABETHMOSS | 13 | "The Handmaid's Tale" actress who plays newspaper archivist Kirby Mazrachi on "Shining Girls": 2 wds. |
| 60% | KEELEYHAWES | 11 | "The Missing" actress who plays Dr. Kira Manning in the "Echoes" spin-off of 18-Across: 2 wds. |
| 60% | HALLEBERRY | 10 | Actress who played Catwoman in the 2004 film "Catwoman": 2 wds. |
| 59% | OTFAGBENLE | 10 | "The Handmaid's Tale" actor who plays a S.H.I.E.L.D. agent in 39-Across (2 wds.) |
| 59% | LESLIEJONES | 11 | Actress who plays the mother of Prince Akeem's son in "Coming 2 America": 2 wds. |
| 59% | HALLEBERRY | 10 | "Tasty" actress who played the superhero Storm in the "X-Men" films: 2 wds. |
| 59% | JANECURTIN | 10 | Actress who played Prymaat from the planet Remulak in 1993's "Coneheads": 2 wds. |
| 59% | ELISABETHMOSS | 13 | "The Handmaid's Tale" star who won the 2017 Emmy Award for Outstanding Lead Actress in a Drama Series (2 wds.) |
| 59% | HAYLEYATWELL | 12 | Actress who plays Grace in the new "Mission: Impossible" movie: 2 wds. |
| 59% | NIALONG | 7 | "The Best Man Holiday" actress who played Brandi in "Boyz n the Hood": 2 wds. |
| 59% | SARAHPAULSON | 12 | "American Horror Story" actress who plays the title character in Netflix's "Ratched": 2 wds. |
| 59% | LIVTYLER | 8 | "Armageddon" actress who played the lead singer's girlfriend Faye in 34-Across: 2 wds. |
| 59% | JULIAROBERTS | 12 | "Pretty Woman" actress who played the title role in 2000's "Erin Brockovich": 2 wds. |
| 58% | ROSIEPEREZ | 10 | "White Men Can't Jump" actress who played Mookie's girlfriend Tina in "Do the Right Thing": 2 wds. |
| 58% | RACHELMCADAMS | 13 | "Doctor Strange" actress who plays the title character's mom in 33-/49-Across: 2 wds. |
| 58% | RACHELMCADAMS | 13 | Actress who plays Annie in the 2018 action comedy film "Game Night": 2 wds. |
| 58% | SUSANSARANDON | 13 | Actress who played Louise, one of the title characters on the run in 1991's "Thelma & Louise": 2 wds. |
| 58% | LESLIEJONES | 11 | "Ghostbusters" actress who plays the mother of Prince Akeem's son in "Coming 2 America": 2 wds. |