| 100% | LESLIEODOMJR | 12 | "Murder on the Orient Express" actor who played Aaron Burr in "Hamilton": 3 wds. |
| 70% | JOHNNYDEPP | 10 | "Murder on the Orient Express" actor who plays retired detective Russell Poole in 47-Across (2 wds.) |
| 63% | PENELOPECRUZ | 12 | "Murder on the Orient Express" actress who plays Laura Ferrari in "Ferrari" (2 wds.) |
| 62% | ALBERTFINNEY | 12 | Actor who played Hercule Poirot in the 1974 film "Murder on the Orient Express": 2 wds. |
| 60% | KENNETHBRANAGH | 14 | Actor who played Hercule Poirot in 2017's "Murder on the Orient Express" and 2022's "Death on the Nile": 2 wds. |
| 59% | KENNETHBRANAGH | 14 | "Murder on the Orient Express" (2017) star who is the only actor to direct himself playing Hercule Poirot (2 wds.) |
| 58% | KENNETHBRANAGH | 14 | "Murder on the Orient Express" and 45-Across star who is the only actor to direct himself playing Hercule Poirot (2 wds.) |
| 58% | ALBERTFINNEY | 12 | "Murder on the Orient Express" (1974) star who is the only actor to be nominated for an Oscar for playing Hercule Poirot (2 wds.) |
| 54% | STEVEMARTIN | 11 | "Dirty Rotten Scoundrels" actor who plays Charles on "Only Murders in the Building" (2 wds.) |
| 54% | ALBERTFINNEY | 12 | "Annie" actor who played Belgian detective Hercule Poirot in the 1974 film "Murder on the Orient Express": 2 wds. |
| 54% | JESSEWILLIAMS | 13 | "Grey's Anatomy" actor who plays a camera operator on "Only Murders in the Building" (2 wds.) |
| 53% | MARTINSHORT | 11 | "Three Amigos" actor who plays a Broadway director/true crime podcaster on "Only Murders in the Building" (2 wds.) |
| 53% | KENNETH | 7 | Actor Branagh who plays Hercule Poirot in 2017's "Murder on the Orient Express" |
| 52% | INGRIDBERGMAN | 13 | "Casablanca" actress who played a Swedish missionary in "Murder on the Orient Express": 2 wds. |
| 51% | LAURENBACALL | 12 | "Key Largo" actress who played an American widow in "Murder on the Orient Express": 2 wds. |
| 50% | SPENCERTRACY | 12 | Actor who played the lawyer based on Clarence Darrow in 32-Across: 2 wds. |
| 50% | TOMMYLEEJONES | 13 | Actor who played baseball's Ty Cobb in the 1994 biopic "Cobb": 3 wds. |
| 50% | ALANHALEJR | 10 | Actor who played the Skipper on "Gilligan's Island": 3 wds., abbr. |
| 49% | FRANKIEMUNIZ | 12 | Actor who played child prodigy Malcolm on "Malcolm in the Middle": 2 wds. |
| 49% | ROBERTDENIRO | 12 | Actor who played 15-Across in the 1987 film "The Untouchables": 3 wds. |
| 49% | ROBERTDENIRO | 12 | "Joy" actor who plays the title character in 18-Across: 3 wds. |
| 48% | AMYRYAN | 7 | Actor who played Holly on The Office and Jan on Only Murders in the Building |
| 48% | FREDRICMARCH | 12 | Actor who played the lawyer based on William Jennings Bryan in 32-Across: 2 wds. |
| 48% | CUBAGOODINGJR | 13 | "Jerry Maguire" actor who played Tre in "Boyz n the Hood": 3 wds. |
| 48% | STEVEMARTIN | 11 | "Only Murders in the Building" actor who plays a character based on Cyrano de Bergerac in the film "Roxanne" (2 wds.) |
| 48% | CHARLIECOX | 10 | Actor who plays the Marvel Comics hero Daredevil in "Daredevil" and "The Defenders" on Netflix (2 wds.) |
| 48% | KYLECHANDLER | 12 | Actor who plays Cathcart in the Hulu miniseries based on 39-Across's "Catch-22" (2 wds.) |
| 48% | ANTHONYMACKIE | 13 | Actor who plays Falcon in the Marvel Cinematic Universe and has been on "Black Mirror": 2 wds. |
| 48% | PETERUSTINOV | 12 | Actor who played Hercule Poirot in the 1978 film "Death on the Nile": 2 wds. |
| 48% | ROBERTDOWNEYJR | 14 | "The Avengers" actor who played the title role in "Chaplin": 3 wds., abbr. |