| 100% | MARKHARMON | 10 | "NCIS" actor who played Dr. Robert Caldwell on "St. Elsewhere": 2 wds. |
| 61% | EDBEGLEYJR | 10 | "Bless This Mess" actor who played Dr. Victor Ehrlich on "St. Elsewhere": 3 wds., abbr. |
| 60% | KELSEYGRAMMER | 13 | Actor who played Dr. Frasier Crane on "Frasier": 2 wds. |
| 59% | OLIVERPLATT | 11 | "Huff" actor who plays Dr. Daniel Charles on "Chicago Med": 2 wds. |
| 56% | JOHNMALKOVICH | 13 | "The New Pope" actor who plays Dr. Adrian Mallory on "Space Force": 2 wds. |
| 55% | MARTINFREEMAN | 13 | "The Hobbit" actor who plays Dr. Watson on the BBC's "Sherlock": 2 wds. |
| 55% | PETERKRAUSE | 11 | "Parenthood" actor who plays fire captain Robert Nash on "9-1-1": 2 wds. |
| 55% | RONLEIBMAN | 10 | "Norma Rae" actor who played Rachel's father, Dr. Leonard Green, on "Friends": 2 wds. |
| 55% | ROBERTSEAN | 10 | With 25-Across, actor who played Dr. James Wilson (based on 47-Across) on the Fox series "House": 2 wds. |
| 55% | TIMROTH | 7 | "Pulp Fiction" actor who played Dr. Cal Lightman on the Fox series "Lie To Me": 2 wds. |
| 54% | HARRISONFORD | 12 | "1923" actor who plays Dr. Paul Rhoades on "Shrinking" (2 wds.) |
| 53% | DAVID | 5 | With 29-Across, "Treme" actor who played Dr. Jack Morrison on "St. Elsewhere" |
| 53% | RYANEGGOLD | 10 | "The Blacklist" actor who plays Dr. Max Goodwin on "New Amsterdam" (2 wds.) |
| 53% | OMIDABTAHI | 10 | "American Gods" actor who plays Dr. Pershing on "The Mandalorian" (2 wds.) |
| 52% | JAMESBROLIN | 11 | "Life in Pieces" actor who played Dr. Steve Kiley on 30-Across (2 wds.) |
| 52% | MARKHARMON | 10 | "Chicago Hope" actor who plays Special Agent Leroy Gibbs on "NCIS": 2 wds. |
| 51% | SPENCER | 7 | Jesse ___, actor who plays Dr. Robert Chase on "House, M.D." |
| 51% | LUCASBLACK | 10 | "American Gothic" actor who plays Special Agent Christopher Lasalle on "NCIS: New Orleans": 2 wds. |
| 51% | CARROLLOCONNOR | 14 | Actor who played Archie on 16-Across: 2 wds. |
| 51% | ANDYKAUFMAN | 11 | Actor who played Latka Gravas on "Taxi": 2 wds. |
| 51% | BILLYPORTER | 11 | Actor who plays Pray Tell on "Pose": 2 wds. |
| 51% | CHRISODONNELL | 13 | "Grey's Anatomy" actor who plays Special Agent G. Callen on "NCIS: Los Angeles": 2 wds. |
| 50% | LARRYHAGMAN | 11 | Actor who played Tony Nelson on "I Dream of Jeannie": 2 wds. |
| 50% | SEANGIAMBRONE | 13 | Actor who plays the geeky boy, Adam, on 18-Across: 2 wds. |
| 50% | IAINARMITAGE | 12 | Actor who plays child prodigy Sheldon Cooper on "Young Sheldon": 2 wds. |
| 50% | HARRYANDERSON | 13 | Actor who played Judge Stone on 18-Across: 2 wds. |
| 50% | DONADAMS | 8 | Actor who played Agent 86 on 16-Across: 2 wds. |
| 50% | WILLIAMDEVANE | 13 | Actor who played Greg Sumner on "Knots Landing": 2 wds. |
| 50% | CHARLIEHEATON | 13 | Actor who played Jonathan Byers on "Stranger Things": 2 wds. |
| 50% | JAMESBROLIN | 11 | Actor who played a physician on 28-Across: 2 wds. |