| 100% | COMET | 5 | "Off On A ___," science fiction novel by Jules Verne about characters that are unwittingly carried off into space |
| 48% | AROUNDTHEMOON | 13 | Science fiction novel by Jules Verne that features a lunar trip: 3 wds. |
| 41% | EARTH | 5 | "Journey to the Center of the ___," science fiction novel by Jules Verne about an expedition to the core of our planet |
| 35% | VENDETTA | 8 | "V for ___," graphic novel by Alan Moore about a dystopian future in the UK that was adapted into a Natalie Portman film |
| 35% | FIVEWEEKSINA | 12 | & 21A 1863 adventure novel by Jules Verne whose central character is Dr Samuel Ferguson |
| 34% | MAN | 3 | "The Invisible ___," 1897 science fiction novel by H.G. Wells that follows a scientist named Griffin |
| 33% | LANDLINE | 8 | Science-fiction novel by 29-Across about a woman who connects with a younger version of her husband on an old rotary phone |
| 33% | THEDRY | 6 | Novel by Australian author Jane Harper that was adapted into a movie starring Eric Bana: 2 wds. |
| 33% | WOMENTALKING | 12 | Novel by 36-Across about an isolated Mennonite community in Bolivia that was adapted by 17-Across into a film starring Frances McDormand, Claire Foy, and Rooney Mara (2 wds.) |
| 33% | TWILIGHT | 8 | 2005 novel by Stephenie Meyer featuring vampires that was adapted into a film series starring Robert Pattinson |
| 32% | STRIPTEASE | 10 | Novel by 44-Across that was made into a movie starring Demi Moore: 2 wds. |
| 32% | READYPLAYERONE | 14 | Science fiction novel by Ernest Cline that released in 2011 and became a NYT Bestseller again in 2018: 3 wds. |
| 32% | ISLAND | 6 | "The ___ of Doctor Moreau," 1896 science fiction novel by H.G. Wells that follows a scientist and his hybrid creations |
| 32% | SKYWARD | 7 | Science fiction series by 24-Across/40-Across about a fighter pilot on a ruined planet |
| 32% | LEGEND | 6 | "I Am ___," 1954 horror novel by Richard Matheson featuring vampires that was adapted into a film starring Will Smith |
| 32% | LOT | 3 | "'Salem's ___," 1975 horror novel by Stephen King featuring vampires that was adapted into a miniseries starring David Soul |
| 32% | SCOTT | 5 | "___ Pilgrim," series of graphic novels by Bryan Lee O'Malley that was adapted into a film starring Michael Cera |
| 32% | THEHATEUGIVE | 12 | Best-selling novel by 40-Across that was adapted into a new movie: 4 wds. |
| 32% | WATCHMEN | 8 | Graphic novel by Alan Moore that is a satire on superheroes |
| 31% | SCARLET | 7 | "The ___ Letter," historical fiction novel by Nathaniel Hawthorne that was an inspiration for the film "Easy A" |
| 31% | BIGLITTLELIES | 13 | Novel by 32-Across that was made into the 2017 HBO murder-mystery miniseries about seemingly perfect lives (3 wds.) |
| 31% | MIND | 4 | "A Beautiful ___" biographical drama based on a novel by Sylvia Nasar which is about a Nobel laureate John Nash |
| 31% | ROOM | 4 | 2010 novel by Emma Donoghue that was adapted into a movie starring Brie Larson |
| 31% | ROAD | 4 | "The ___," 2006 novel by Cormac McCarthy that was adapted into a 2009 survival film |
| 31% | GOD | 3 | "Child of ___," 1973 novel by Cormac McCarthy that was adapted into a 2013 film |
| 31% | OUTER | 5 | "___ Dark," 1968 novel by Cormac McCarthy that was adapted into a 2009 short film |
| 31% | SLEEPER | 7 | "The ___ Awakes," 1899 dystopian science fiction novel by writer H.G. Wells about a man who wakes up after a 203-year slumber |
| 30% | DAVINCI | 7 | "The ___ Code," 2003 novel by Dan Brown that was made into a film: 2 wds. |
| 30% | CARRIE | 6 | 1974 novel by Stephen King that was adapted into a 1976 film starring Sissy Spacek |
| 30% | SYNDROME | 8 | Science fiction survival horror video game, released in 2016 be Camel 101, that takes place inside a drifting space ship |