| 100% | MISS | 4 | "Our ___ Brooks," 1940s radio show by CBS adapted into a sitcom, featuring a witty, sardonic high school English teacher |
| 26% | APBIO | 5 | Sitcom that starred Glenn Howerton as a high school science teacher: 2 wds. |
| 24% | TWILIGHT | 8 | 2005 novel by Stephenie Meyer featuring vampires that was adapted into a film series starring Robert Pattinson |
| 23% | LOT | 3 | "'Salem's ___," 1975 horror novel by Stephen King featuring vampires that was adapted into a miniseries starring David Soul |
| 23% | LEGEND | 6 | "I Am ___," 1954 horror novel by Richard Matheson featuring vampires that was adapted into a film starring Will Smith |
| 23% | APBIO | 5 | Sitcom starring Glenn Howerton as a high-school science teacher |
| 22% | BREAKINGBAD | 11 | Popular American neo-western crime drama by Vince Gilligan about a high school chemistry teacher diagnosed with lung cancer: 2 wds. |
| 22% | AIDA | 4 | Opera adapted into a musical by Elton John |
| 22% | MADAME | 6 | Title for many a high school French teacher |
| 21% | APBIO | 5 | Sitcom set in a high school |
| 21% | DUFFYSTAVERN | 12 | 1940s hit radio show featuring the bartender Archie |
| 21% | SEGMENT | 7 | Regular feature on a radio show |
| 21% | WORKINGCLASSES | 14 | Job for a high school teacher? |
| 21% | GYM | 3 | High school class that often requires a shower afterward |
| 21% | CALLERS | 7 | People who phone into a radio show |
| 21% | GLEE | 4 | TV show about a high school choir |
| 20% | GLEE | 4 | TV series about a high school show choir |
| 20% | SHADOWANDBONE | 13 | Fantasy trilogy by 40-Across adapted into a 2021 Netflix series (3 wds.) |
| 20% | BUNCH | 5 | "The Brady ___," 1969 sitcom featuring a suburban household that inspired the show "WandaVision" |
| 20% | BAYSIDE | 7 | ___ High School, fictional school featured in "Saved by the Bell" |
| 20% | APBIO | 5 | Peacock show about a high school in Toledo, OH |
| 20% | SOPHIESCHOICE | 13 | 1979 novel by 47-Across adapted into a film starring 30-Across (2 wds.) |
| 20% | SEED | 4 | "The Bad ___," horror novel written by William March which was adapted into a movie |
| 20% | ROOM | 4 | 2010 novel by Emma Donoghue that was adapted into a movie starring Brie Larson |
| 20% | ROAD | 4 | "The ___," 2006 novel by Cormac McCarthy that was adapted into a 2009 survival film |
| 20% | GOD | 3 | "Child of ___," 1973 novel by Cormac McCarthy that was adapted into a 2013 film |
| 20% | OUTER | 5 | "___ Dark," 1968 novel by Cormac McCarthy that was adapted into a 2009 short film |
| 20% | GLEE | 4 | Television show about a high school choir starring Lea Michele |
| 20% | LANG | 4 | A.P. ___ (high school English course, for short) |
| 20% | FIGHT | 5 | "___ Club," 1996 novel by Chuck Palahniuk which was adapted into a film by David Fincher |