| 100% | STONE | 5 | "Rodney ___," gothic mystery novel by Arthur Conan Doyle that was adapted as "The House of Temperley" |
| 41% | POLE | 4 | "The Captain of the ___-Star," short story by Arthur Conan Doyle that was published in the Temple Bar |
| 37% | FOUR | 4 | "The Sign of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 37% | BASKERVILLES | 12 | "The Hound of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 36% | ALIVE | 5 | "Luckiest Girl ___," 2015 novel by Jessica Knoll that was adapted into 2022 mystery thriller movie of the same name |
| 36% | LANDOFMIST | 10 | The —, 1926 novel by Arthur Conan Doyle |
| 36% | LIST | 4 | "The Guest ___," 2020 novel by Lucy Foley that is a murder mystery set against the backdrop of a wedding |
| 35% | SIGNOFFOUR | 10 | The —, 1890 novel by Arthur Conan Doyle featuring Sherlock Holmes |
| 34% | LOT | 3 | "___ No. 249," gothic horror short story by Arthur Conan Doyle that influenced the Mummy horror genre |
| 34% | VALLEY | 6 | "The Mystery of the Sasassa ___," first published work by Arthur Conan Doyle |
| 34% | BELL | 4 | Joseph ___, surgeon whom Arthur Conan Doyle cites as inspiration for the character of Sherlock Holmes |
| 34% | HANNIBAL | 8 | One of the best-selling gothic novels of the 90s written by Thomas Harris that revolves around Lecter's life as a serial killer |
| 33% | THEDOINGSOF | 11 | & 25A 1892 novel by Arthur Conan Doyle |
| 33% | MICAH | 5 | & 21A 1889 novel by Arthur Conan Doyle |
| 33% | RAMA | 4 | "Rendezvous with ___," 1973 novel by Arthur C. Clarke that is set in the 2130s |
| 33% | SHIRLEYJACKSON | 14 | Writer whose novel "The Haunting of Hill House" was adapted as the 1999 film "The Haunting" (2 wds.) |
| 33% | METRO | 5 | "___ 2033," video game that was inspired by Dmitry Glukhovsky novel of the same title |
| 33% | SHIPS | 5 | "A Thousand ___," novel by Natalie Haynes that is a retelling of the Trojan War |
| 32% | STUDY | 5 | "A ___ in Scarlet" (first Sherlock Holmes novel by Arthur Conan Doyle) |
| 32% | HAMMER | 6 | "The ___ of God," 1993 sci-fi novel by Arthur C. Clarke that is set in the year 2109 |
| 32% | INTERVIEW | 9 | "___ with the Vampire," 1976 gothic horror novel by Anne Rice that was adapted into a film starring Brad Pitt |
| 32% | KILLINGFLOOR | 12 | Debut novel by 25-Across that was the basis for the first season of "Reacher" (2 wds.) |
| 32% | THOUSAND | 8 | "A ___ Ships," 2019 novel by Natalie Haynes that is a modern retelling of the Trojan War mythology |
| 31% | SHINING | 7 | "The ___ Girls," 2013 novel by Lauren Beukes that was adapted into 2022 TV series of the same name |
| 31% | NILE | 4 | "Death on the ___," 1937 novel by Agatha Christie that was adapted into the eponymous 2022 mystery film |
| 31% | THEMANSION | 10 | 1959 novel by William Faulkner that is the last of the trilogy on the Snopes family: 2 wds. |
| 31% | WHITENOISE | 10 | Novel by 44-Across that was adapted as a 2022 film by Noah Baumbach (2 wds.) |