| 100% | MIKEMYERS | 9 | "SNL" alum who played the title roles in the "Austin Powers" and "Shrek" movies: 2 wds. |
| 67% | EWANMCGREGOR | 12 | "Beauty and the Beast" actor who plays the title role in the new movie "Christopher Robin": 2 wds. |
| 61% | BENPLATT | 8 | "The Politician" star who plays the title role in the movie adaptation of "Dear Evan Hansen": 2 wds. |
| 60% | JULIEANDREWS | 12 | "The Princess Diaries" actress who played the title role in the 1957 TV movie musical "Cinderella" (2 wds.) |
| 59% | MYERS | 5 | Mike —, actor who played the title role in films Wayne's World and Austin Powers: International Man of Mystery |
| 59% | CAMILACABELLO | 13 | "Trolls Band Together" voice actress who played the title role in the 2021 movie musical "Cinderella" (2 wds.) |
| 57% | HARRISONFORD | 12 | "The Fugitive" actor who plays the title role in "Indiana Jones and the Dial of Destiny" (2 wds.) |
| 57% | GINARODRIGUEZ | 13 | Former "The Bold and the Beautiful" actress who plays the title role in 41-Across (2 wds.) |
| 56% | MATTHEWRHYS | 11 | "The Americans" actor who plays the title role in HBO's "Perry Mason": 2 wds. |
| 56% | JULIAROBERTS | 12 | "Pretty Woman" actress who played the title role in 2000's "Erin Brockovich": 2 wds. |
| 56% | OLIVIAMUNN | 10 | "The Predator" actress who plays the title role in "Violet": 2 wds. |
| 55% | JASONMOMOA | 10 | "Conan the Barbarian" star who plays the title role in "Aquaman": 2 wds. |
| 55% | TONYTODD | 8 | "Final Destination" actor who plays the title role in 16-Across: 2 wds. |
| 55% | EDDIEMURPHY | 11 | "Coming to America" actor who played the title role in 1998's "Dr. Dolittle": 2 wds. |
| 55% | EZRAMILLER | 10 | Actor who plays the title character in the new movie "The Flash": 2 wds. |
| 55% | HENRYFONDA | 10 | "On Golden Pond" actor who played the title role in 32-Across: 2 wds. |
| 54% | DENNISQUAID | 11 | "Flight of the Phoenix" actor who plays the title role in 16-Across: 2 wds. |
| 54% | FERDIASHAW | 10 | Young actor who plays the title character in the 2020 movie "Artemis Fowl": 2 wds. |
| 54% | MIKEMYERS | 9 | "SNL" cast member (1989-1995) who voiced the title character in the "Shrek" movies: 2 wds. |
| 53% | TARONEGERTON | 12 | "Rocketman" actor who plays the title role in the 2018 film "Robin Hood" (2 wds.) |
| 53% | RUSSELLCROWE | 12 | "Gladiator" actor who plays the title role in the 2010 film "Robin Hood" (2 wds.) |
| 53% | DEREKJACOBI | 11 | "The King's Speech" actor who plays the title role in the film "Cyrano de Bergerac" (2 wds.) |
| 53% | KEANUREEVES | 11 | "The Matrix Resurrections" actor who plays the title role in "John Wick: Chapter 4" (2 wds.) |
| 53% | JULIEANDREWS | 12 | Actress who won an Oscar for playing the title role in 39-Across: 2 wds. |
| 53% | JONFAVREAU | 10 | Actor who plays Happy Hogan in the Marvel movies, and plays the same role in the upcoming "Spider-Man: Homecoming": 2 wds. |
| 53% | HELENMIRREN | 11 | "The Queen" actress who plays the title role in "Golda" (2 wds.) |
| 52% | CHRISROCK | 9 | "SNL" alum who hosted the Oscars in 2005 and voiced Marty the zebra in the "Madagascar" movies: 2 wds. |
| 52% | JAMESMCAVOY | 11 | "X-Men: Apocalypse" star who played the title character of 28-Across in a 2015 movie: 2 wds. |
| 52% | MYERS | 5 | Mike ___, actor who played the role of the hero and the villain in the movie "Austin Powers" |
| 52% | MICHAELKEATON | 13 | "Mr. Mom" actor who played the title role in 40-Across (2 wds.) |