| 100% | MIKEMYERS | 9 | "SNL" cast member (1989-1995) who voiced the title character in the "Shrek" movies: 2 wds. |
| 69% | BILLYCRYSTAL | 12 | "SNL" cast member (1984-1985) who voiced Mike Wazowski in the "Monsters, Inc." movies: 2 wds. |
| 65% | CHRISROCK | 9 | "Saturday Night Live" cast member (1990-1993) who voiced the zebra Marty in the "Madagascar" movies: 2 wds. |
| 61% | EZRAMILLER | 10 | Actor who plays the title character in the new movie "The Flash": 2 wds. |
| 61% | KARENFUKUHARA | 13 | "Suicide Squad" actress who voices the title character in 14-/32-Across: 2 wds. |
| 61% | FERDIASHAW | 10 | Young actor who plays the title character in the 2020 movie "Artemis Fowl": 2 wds. |
| 60% | JAMESCORDEN | 11 | "The Late Late Show" host who voices the title character in 18-Across: 2 wds. |
| 59% | MICHAELCERA | 11 | "Arrested Development" actor who voices the title character in Netflix's "Scott Pilgrim Takes Off": 2 wds. |
| 59% | MIKEMYERS | 9 | "SNL" alum who played the title roles in the "Austin Powers" and "Shrek" movies: 2 wds. |
| 58% | DIANEKEATON | 11 | "Annie Hall" actress who voiced the title character's mother in 18-Across: 2 wds. |
| 57% | ADAM | 4 | Sandler who voices the title character in the animated movie "Leo" |
| 57% | SETH | 4 | MacFarlane who voices the title character in the upcoming "Ted 2" |
| 57% | CHRISEVANS | 10 | "Knives Out" actor who voices the title character in "Lightyear" (2 wds.) |
| 56% | ALEC | 4 | Baldwin who voices the title character in the "Boss Baby" movies |
| 55% | MAE | 3 | Actress Whitman who voices the title character in the "Tinker Bell" movies |
| 55% | CAMILACABELLO | 13 | "Trolls Band Together" voice actress who played the title role in the 2021 movie musical "Cinderella" (2 wds.) |
| 55% | JAMESMCAVOY | 11 | "X-Men: Apocalypse" star who played the title character of 28-Across in a 2015 movie: 2 wds. |
| 54% | IRENEBEDARD | 11 | Actress who voiced the title role in "Pocahontas": 2 wds. |
| 54% | TOMHARDY | 8 | "Inception" actor who plays the title character in "Venom": 2 wds. |
| 54% | MARGOTROBBIE | 12 | "Babylon" actress who plays the title character in "Barbie": 2 wds. |
| 53% | PETERDINKLAGE | 13 | "Game of Thrones" actor who plays the title character in "The Toxic Avenger": 2 wds. |
| 53% | REBBROWN | 8 | Actor who played the titular character in the TV movie "Captain America" in 1979: 2 wds. |
| 53% | SARAHPAULSON | 12 | "American Horror Story" actress who plays the title character in Netflix's "Ratched": 2 wds. |
| 52% | EMILYBLUNT | 10 | "The Girl on the Train" star who plays the title character in "Mary Poppins Returns": 2 wds. |
| 52% | ANSELELGORT | 11 | "The Fault in Our Stars" actor who plays the title character in "Baby Driver": 2 wds. |
| 51% | VITOCORLEONE | 12 | Character who has the title role in 15-Across: 2 wds. |
| 51% | EWANMCGREGOR | 12 | "Beauty and the Beast" actor who plays the title role in the new movie "Christopher Robin": 2 wds. |
| 51% | RICHARDCASTLE | 13 | Writer who was the title character in a 2009-2016 crime series: 2 wds. |
| 51% | KENNETHBRANAGH | 14 | Actor who directed and played the title character in 1996's "Hamlet": 2 wds. |
| 51% | TARONEGERTON | 12 | "Kingsman: The Golden Circle" actor who plays the title character in 16-Across: 2 wds. |