| 100% | PARK | 4 | "South ___," popular animated sitcom created by Trey Parker and Matt Stone |
| 73% | SOUTHPARK | 9 | Emmy-winning animated Comedy Central sitcom created by Trey Parker and Matt Stone: 2 wds. |
| 55% | BOOKOF | 6 | "The ___" (with 35-Across, satirical Broadway musical created by Trey Parker, Robert Lopez, and Matt Stone: 2 wds. |
| 52% | FUTURAMA | 8 | Popular animated sitcom created by Matt Groening about Earth in the year 3000 |
| 46% | SOUTHPARK | 9 | Animated series starring Trey Parker and Matt Stone that's named for a fictional town in Colorado: 2 wds. |
| 46% | BOBS | 4 | "___ Burgers," popular animated sitcom created by Loren Bouchard |
| 40% | ARCHER | 6 | Popular adult animated sitcom created by Adam Reed about a dysfunctional spy agency |
| 36% | GUY | 3 | "___ Guy," animated sitcom created by Seth MacFarlane |
| 36% | BOBS | 4 | "___ Burgers," animated sitcom created by Loren Bouchard |
| 36% | GUY | 3 | "Family ___," American animated sitcom created by Seth MacFarlane |
| 33% | THESIMPSONS | 11 | Popular American animated sitcom by Matt Groening which is a satirical depiction of working-class life: 2 wds. |
| 33% | SUPERFUNNIGHT | 13 | ABC sitcom created by and starring 18-Across: 3 wds. |
| 33% | CURB | 4 | "___ Your Enthusiasm," semi-autobiographical sitcom created by and starring Larry David |
| 32% | EVERYBODY | 9 | "___ Hates Chris," semi-autobiographical sitcom created by and narrated by Chris Rock |
| 31% | TREY | 4 | Parker who created "South Park" with Matt Stone |
| 29% | UPTHEWOMEN | 10 | 2010s BBC TV sitcom starring, created and written by Jessica Hynes |
| 28% | STAN | 4 | "South Park" kid voiced by Trey Parker |
| 28% | IDREAMOFJEANNIE | 15 | Sitcom created by Sidney Sheldon |
| 28% | SCHITTSCREEK | 12 | Canadian sitcom created by 26-Across and his son Daniel that won a record seven Emmys in 2020 (2 wds.) |
| 28% | KEN | 3 | ___ and Barbie, popular fictional couple created by Mattel |
| 27% | HOMER | 5 | Popular television character voiced by Dan Castellaneta in the animated sitcom "The Simpsons" |
| 26% | GUY | 3 | "Family ___," 1999 sitcom created by Seth MacFarlane |
| 26% | GUY | 3 | "Family ___" (1999 sitcom created by Seth MacFarlane) |
| 26% | TWEETY | 6 | Animated canary created by Bob Clampett |
| 25% | DALE | 4 | "Chip 'n ___: Rescue Rangers," American animated comedy series created by Tad Stones and Alan Zaslove |
| 25% | OLAF | 4 | Snowman created by Elsa and Anna |
| 25% | ROCKYROAD | 9 | Popular ice cream flavor created by William Dreyer which contains nuts and marshmallows: 2 wds. |
| 25% | TOM | 3 | "___ and Jerry," American animated series created by William Hanna and Joseph Barbera |
| 25% | MYSPACE | 7 | Social networking service created by Tom Anderson and Chris DeWolfe that was popular in the 2000s |
| 24% | STEWIE | 6 | Animated-sitcom baby who both kills and is killed by his own mother |