| 100% | RACHELMCADAMS | 13 | "Spotlight" actress who plays surgeon Christine Palmer in 32-Across: 2 wds. |
| 66% | MAYARUDOLPH | 11 | "Bridesmaids" actress who plays Christine in 32-Across: 2 wds. |
| 63% | RACHELMCADAMS | 13 | Actress who plays Dr. Christine Palmer in "Doctor Strange in the Multiverse of Madness": 2 wds. |
| 59% | ELLENBARKIN | 11 | "Sea of Love" actress who plays Janine "Smurf" Cody in 32-Across: 2 wds. |
| 57% | JACKIWEAVER | 11 | "Silver Linings Playbook" actress who plays Sandy in 32-Across: 2 wds. |
| 56% | MIAWASIKOWSKA | 13 | Actress who played the daughter of 14- and 32-Across in "The Kids Are All Right": 2 wds. |
| 56% | HOLLYHUNTER | 11 | "The Piano" actress who played "Ed" McDunnough in 32-Across: 2 wds. |
| 54% | RACHELMCADAMS | 13 | "Spotlight" actress who plays a surgeon in "Doctor Strange in the Multiverse of Madness" (2 wds.) |
| 53% | RACHELMCADAMS | 13 | "Spotlight" actress who plays Annie in "Game Night": 2 wds. |
| 52% | RACHELMCADAMS | 13 | "True Detective" actress who played 32-Across in the Guy Ritchie film "Sherlock Holmes" (2 wds.) |
| 52% | RACHELMCADAMS | 13 | "Spotlight" actress who played Allie Hamilton in 44-Across (2 wds.) |
| 52% | BRITTANYMURPHY | 14 | Actress who played Eminem's love interest in "8 Mile," and met an untimely death, aged only 32: 2 wds. |
| 51% | JULIANNEMOORE | 13 | "Still Alice" actress who plays 19-Across later in life: 2 wds. |
| 50% | JUDYGARLAND | 11 | "A Star Is Born" actress who plays 42-Across in 32-Across (2 wds.) |
| 50% | ELLIEKEMPER | 11 | Actress who plays the lead role in 12-/24-Across: 2 wds. |
| 50% | SANDRABULLOCK | 13 | "Speed" actress who played Lieutenant Lenina Huxley in 15-Across: 2 wds. |
| 50% | ARIGRAYNOR | 10 | "Fringe" actress who costars in 32-Across: 2 wds. |
| 50% | ANYATAYLORJOY | 13 | "Glass" actress who played 19-Across in a 2020 film: 2 wds., hyph. |
| 50% | MADSMIKKELSEN | 13 | "Hannibal" actor who plays the villain Kaecilius in 32-Across: 2 wds. |
| 50% | EMMATHOMPSON | 12 | Oscar-winning actress who plays P.L. Travers, author of the novel "Mary Poppins," in 32-Across: 2 wds. |
| 50% | LEAMICHELE | 10 | Actress who plays 17-Across' girlfriend and was 29-Across' girlfriend in real life: 2 wds. |
| 49% | JENNIFERLOPEZ | 13 | "Hustlers" actress who played US marshal Karen Sisco in 23-/35-Across: 2 wds. |
| 49% | MAYARUDOLPH | 11 | "Bridesmaids" actress who voices Smiler in 32-Across: 2 wds. |
| 49% | MELISSALEO | 10 | "The Fighter" actress who costars in 32-Across: 2 wds. |
| 49% | SANDRADEE | 9 | Actress who played Gidget in 1959: 2 wds. |
| 49% | HAYLEYATWELL | 12 | "Agent Carter" actress who plays 18-Across's wife Evelyn in "Christopher Robin": 2 wds. |
| 49% | JULIECHRISTIE | 13 | "Shampoo" actress who played Lara in the 1965 film version of 19-Across: 2 wds. |
| 49% | MARKIEPOST | 10 | Actress who played public defender Christine Sullivan on 18-Across: 2 wds. |
| 49% | ERICBANA | 8 | Actor who played 32-Across in a 2003 film: 2 wds. |
| 49% | EDWARDNORTON | 12 | Actor who played 32-Across in a 2008 film: 2 wds. |