| 100% | TAKEI | 5 | "Star Trek" actor George who has had cameos on "The Big Bang Theory" and "King of the Nerds" |
| 51% | WIL | 3 | Actor Wheaton who has guest appearances on "The Big Bang Theory" |
| 50% | WILWHEATON | 10 | "Star Trek: The Next Generation" actor who guest stars as himself on "The Big Bang Theory" (2 wds.) |
| 44% | WIL | 3 | "Star Trek: TNG" actor Wheaton who made several guest appearances on "The Big Bang Theory" |
| 44% | WIL | 3 | Actor Wheaton who had a recurring role on "The Big Bang Theory" |
| 44% | DESI | 4 | Actor Arnaz who has two stars on the Hollywood Walk of Fame |
| 44% | JUDDHIRSCH | 10 | "Superior Donuts" actor who guest stars as Leonard's dad on "The Big Bang Theory" (2 wds.) |
| 43% | WIL | 3 | Actor Wheaton who occasionally guest-stars on "The Big Bang Theory" |
| 43% | WIL | 3 | Actor Wheaton who's guest-starred on "The Big Bang Theory" |
| 43% | LEVAR | 5 | ___ Burton, "Star Trek" actor who appeared on a "Sheldon Cooper Presents: Fun with Flags" segment in "The Big Bang Theory" |
| 43% | STEVEWOZNIAK | 12 | Co-founder of Apple and noted philanthropist who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 43% | ELONMUSK | 8 | CEO of SpaceX and product architect of Tesla who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 42% | DEAN | 4 | "Breaking Bad" actor Norris who had a recurring role on "The Big Bang Theory" |
| 42% | JIMPARSONS | 10 | Actor who portrayed Sheldon Cooper in "The Big Bang Theory," and is the narrator in "Young Sheldon": 2 wds. |
| 41% | ADAMWEST | 8 | Batman actor from the 1960s who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 41% | JIMPARSONS | 10 | Actor who plays Sheldon on "The Big Bang Theory" (2 wds.) |
| 41% | JOHNNYGALECKI | 13 | Actor who plays Leonard on "The Big Bang Theory" (2 wds.) |
| 41% | KUNALNAYYAR | 11 | Actor who played Raj on “The Big Bang Theory” |
| 40% | RAJ | 3 | Pal of Sheldon and Leonard on "The Big Bang Theory" |
| 40% | AMY | 3 | Friend of Penny and Bernadette on "The Big Bang Theory" |
| 40% | SMOOT | 5 | George ___, Nobel prize winner in Physics who cameoed in "The Big Bang Theory" |
| 40% | RAJ | 3 | Pal of Howard, Sheldon, and Leonard on "The Big Bang Theory" |
| 39% | BIALIK | 6 | The Big Bang Theory and Blossom star Mayim |
| 39% | IRA | 3 | ___ Flatow, engineer and "Newton's Apple" host who cameoed in "The Big Bang Theory" |
| 39% | BOB | 3 | ___ Newhart, stand-up comedian and actor who played Arthur Jeffries in "The Big Bang Theory" |
| 38% | PARSONS | 7 | Jim who plays Sheldon on The Big Bang Theory |
| 38% | WIL | 3 | Wheaton who plays himself on The Big Bang Theory |
| 38% | KATEYSAGAL | 10 | "Sons of Anarchy" actress who played Penny's mother on "The Big Bang Theory" (2 wds.) |
| 38% | LAURIEMETCALF | 13 | "Lady Bird" actress who guest stars as Sheldon's mom on "The Big Bang Theory" (2 wds.) |
| 38% | MAYIMBIALIK | 11 | Former "Blossom" and "The Big Bang Theory" star who co-hosts "Jeopardy!" (2 wds,) |