| 100% | COLMMEANEY | 10 | "Star Trek: Deep Space Nine" actor who plays Bernie Ohls in "Marlowe" (2 wds.) |
| 68% | AVERYBROOKS | 11 | Actor who played Captain Benjamin Sisko on "Star Trek: Deep Space Nine": 2 wds. |
| 61% | AVERYBROOKS | 11 | "Spenser: For Hire" actor who played Captain Sisko on "Star Trek: Deep Space Nine" (2 wds.) |
| 52% | CHRISPINE | 9 | Actor who plays James T. Kirk in the "Star Trek" reboot films (2 wds.) |
| 52% | CHANNINGTATUM | 13 | Actor who plays one of the studio's stars in 18-Across: 2 wds. |
| 51% | LEONARDNIMOY | 12 | Actor who meets his younger self, played by Zachary Quinto, in the 2009 film "Star Trek": 2 wds. |
| 50% | VALKILMER | 9 | Actor who played rock star Jim Morrison in the 1991 film "The Doors": 2 wds. |
| 50% | RAMIMALEK | 9 | Actor who played rock star Freddie Mercury in the 2018 film "Bohemian Rhapsody": 2 wds. |
| 50% | TERRYCREWS | 10 | Actor who plays Detective Jeffords in the sitcom "Brooklyn Nine-Nine": 2 wds. |
| 50% | DAVECHAPPELLE | 13 | "Undercover Brother" actor who plays Noodles in "A Star Is Born": 2 wds. |
| 50% | PATRICKSTEWART | 14 | "Star Trek: The Next Generation" actor who played Charles Xavier in "X-Men": 2 wds. |
| 50% | JOHNCHO | 7 | Actor who has played Hikaru Sulu in "Star Trek" films since 2009 (2 wds.) |
| 50% | ANTHONYRAPP | 11 | "Star Trek: Discovery" actor who played Mark Cohen in the original Broadway cast of "Rent": 2 wds. |
| 50% | ZACHARYQUINTO | 13 | "Star Trek Beyond" actor who played Harold in "The Boys in the Band": 2 wds. |
| 49% | BILLBLACKBURN | 13 | Actor who was originally named William and played Lt Hadley, and had other uncredited roles in "Star Trek: The Original Series": 2 wds. |
| 49% | DOUGJONES | 9 | "Star Trek: Discovery" actor who plays recurring character Baron Afanas in "What We Do in the Shadows": 2 wds. |
| 48% | GENEKELLY | 9 | "Brigadoon" actor who played a silent film star moving into talkies in "Singin' in the Rain": 2 wds. |
| 47% | WILLIAMSHATNER | 14 | "Star Trek" star who played a murderous actor on "Columbo": 2 wds. |
| 47% | PATRICKSTEWART | 14 | Actor who played Captain Jean-Luc Picard on "Star Trek: The Next Generation": 2 wds. |
| 47% | BRADLEYCOOPER | 13 | "A Star Is Born" actor who plays Leonard Bernstein in "Maestro": 2 wds. |
| 47% | ANTHONYRAMOS | 12 | "A Star Is Born" actor who played Philip Hamilton in "Hamilton": 2 wds. |
| 47% | WAYNEKNIGHT | 11 | "Jurassic Park" actor who played publicist Stan Podolak in "Space Jam": 2 wds. |
| 46% | WILLIAMSHATNER | 14 | Actor who first played James T. Kirk, the captain played by Chris Pine in the new "Star Trek" films (2 wds.) |
| 46% | BRYANCRANSTON | 13 | American actor who played the lead in "Breaking Bad" and also starred in "Malcolm in the Middle": 2 wds. |
| 46% | BRUCEDERN | 9 | Actor who plays Woody Grant in "Nebraska": 2 wds. |
| 46% | STEVECARELL | 11 | Actor who plays Donald Rumsfeld in "Vice": 2 wds. |
| 46% | MANNYJACINTO | 12 | Actor who played Yao on "Nine Perfect Strangers" and costarred in 29- and 42-Across: 2 wds. |
| 46% | PETERMAYHEW | 11 | 7'3" actor who played Chewbacca in the "Star Wars" movies until 2015: 2 wds. |
| 46% | HARRISONFORD | 12 | "Star Wars" actor who played cop Rick Deckard in 13-Across: 2 wds. |
| 46% | JASONMOMOA | 10 | Actor who plays Aquaman in 30-Across: 2 wds. |