| 100% | JEANLUCPICARD | 13 | "Star Trek: The Next Generation" captain played by Patrick Stewart: 2 wds., hyph. |
| 65% | WESLEYCRUSHER | 13 | "Star Trek: The Next Generation" ensign played by Wil Wheaton: 2 wds. |
| 58% | JEANLUCPICARD | 13 | "Star Trek: The Next Generation" captain: 2 wds. |
| 56% | GEORDILAFORGE | 13 | "Star Trek: The Next Generation" engineer played by LeVar Burton: 3 wds. |
| 54% | PATRICKSTEWART | 14 | "Star Trek: The Next Generation" actor who played Charles Xavier in "X-Men": 2 wds. |
| 53% | PATRICKSTEWART | 14 | Actor who played Captain Jean-Luc Picard on "Star Trek: The Next Generation": 2 wds. |
| 51% | PICARD | 6 | "Star Trek" captain played by Patrick Stewart |
| 49% | STAR | 4 | "___ Trek: The Next Generation," 1987 TV series starring Patrick Stewart as Jean-Luc Picard |
| 49% | RIKER | 5 | "Star Trek: The Next Generation" first officer played by Jonathan Frakes |
| 49% | PATRICKSTEWART | 14 | "X-Men" actor who played Captain Picard on "Star Trek: The Next Generation" (2 wds.) |
| 46% | DEANNA | 6 | ___ Troi ("Star Trek: The Next Generation" character played by Marina Sirtis) |
| 46% | WILWHEATON | 10 | "Star Trek: The Next Generation" actor who guest stars as himself on "The Big Bang Theory" (2 wds.) |
| 45% | WILWHEATON | 10 | "Star Trek: The Next Generation" actor who voices amnesiac chef Earl Harlan, a character on 15-/51-Across: 2 wds. |
| 44% | AHAB | 4 | Captain played by Patrick Stewart |
| 44% | BEVERLY | 7 | With 49-Across, "Star Trek: The Next Generation" doctor played by Gates McFadden |
| 44% | JACKSPARROW | 11 | Pirate captain played by Johnny Depp in "Pirates of the Caribbean": 2 wds. |
| 44% | STEWART | 7 | Patrick —, actor who played Captain Jean-Luc Picard in US television series Star Trek: The Next Generation |
| 44% | LUC | 3 | "Star Trek: The Next Generation" captain Jean-___ Picard |
| 44% | JEAN | 4 | "Star Trek: The Next Generation" captain ___-Luc Picard |
| 44% | LEONARDNIMOY | 12 | Actor who meets his younger self, played by Zachary Quinto, in the 2009 film "Star Trek": 2 wds. |
| 43% | DATA | 4 | Lt. Commander ___, robot from "Star Trek: The Next Generation," played by Brent Spiner |
| 42% | WORF | 4 | Klingon played by Michael Dorn on "Star Trek: The Next Generation" |
| 42% | DATA | 4 | Android played by Brent Spiner on "Star Trek: The Next Generation" |
| 42% | JAMESTKIRK | 10 | "Star Trek" character played by William Shatner, who is the captain of the starship USS Enterprise: 3 wds. |
| 42% | RIKER | 5 | Will played by Jonathan Frakes on “Star Trek: The Next Generation” |
| 42% | WORF | 4 | Klingon played by Michael Dorn on “Star Trek: The Next Generation” |
| 41% | LEVARBURTON | 11 | "Star Trek: The Next Generation" actor who learns his ancestry on the 10th season of "Finding Your Roots" (2 wds.) |
| 41% | JOHNSTEED | 9 | Spy played by Patrick Macnee on "The Avengers": 2 wds. |
| 40% | STEWART | 7 | Patrick ___, "Star Trek: The Next Generation" actor |
| 40% | JEAN | 4 | ___-Luc Picard ("Star Trek: The Next Generation" captain) |