| 100% | GEORDILAFORGE | 13 | "Star Trek: The Next Generation" engineer played by LeVar Burton: 3 wds. |
| 70% | GEORDILAFORGE | 13 | "Star Trek" character played by LeVar Burton, who is the chief engineer of the USS Enterprise-D: 3 wds. |
| 62% | WESLEYCRUSHER | 13 | "Star Trek: The Next Generation" ensign played by Wil Wheaton: 2 wds. |
| 60% | JEANLUCPICARD | 13 | "Star Trek: The Next Generation" captain played by Patrick Stewart: 2 wds., hyph. |
| 53% | RIKER | 5 | "Star Trek: The Next Generation" first officer played by Jonathan Frakes |
| 51% | PATRICKSTEWART | 14 | "Star Trek: The Next Generation" actor who played Charles Xavier in "X-Men": 2 wds. |
| 51% | LEVAR | 5 | "Star Trek: The Next Generation" star Burton |
| 50% | DEANNA | 6 | ___ Troi ("Star Trek: The Next Generation" character played by Marina Sirtis) |
| 50% | GEORDI | 6 | LeVar Burton's "Star Trek: The Next Generation" character, ___ La Forge |
| 48% | BEVERLY | 7 | With 49-Across, "Star Trek: The Next Generation" doctor played by Gates McFadden |
| 47% | DATA | 4 | Lt. Commander ___, robot from "Star Trek: The Next Generation," played by Brent Spiner |
| 46% | JEANLUCPICARD | 13 | "Star Trek: The Next Generation" captain: 2 wds. |
| 46% | WORF | 4 | Klingon played by Michael Dorn on "Star Trek: The Next Generation" |
| 46% | DATA | 4 | Android played by Brent Spiner on "Star Trek: The Next Generation" |
| 46% | WILWHEATON | 10 | "Star Trek: The Next Generation" actor who guest stars as himself on "The Big Bang Theory" (2 wds.) |
| 45% | JAMESTKIRK | 10 | "Star Trek" character played by William Shatner, who is the captain of the starship USS Enterprise: 3 wds. |
| 45% | RIKER | 5 | Will played by Jonathan Frakes on “Star Trek: The Next Generation” |
| 45% | WORF | 4 | Klingon played by Michael Dorn on “Star Trek: The Next Generation” |
| 43% | LEVAR | 5 | Actor Burton who played Geordi La Forge on "Star Trek: The Next Generation" |
| 41% | PATRICKSTEWART | 14 | Actor who played Captain Jean-Luc Picard on "Star Trek: The Next Generation": 2 wds. |
| 41% | LEVARBURTON | 11 | "Star Trek: The Next Generation" actor who learns his ancestry on the 10th season of "Finding Your Roots" (2 wds.) |
| 41% | WILWHEATON | 10 | "Star Trek: The Next Generation" actor who voices amnesiac chef Earl Harlan, a character on 15-/51-Across: 2 wds. |
| 41% | PATRICKSTEWART | 14 | "X-Men" actor who played Captain Picard on "Star Trek: The Next Generation" (2 wds.) |
| 40% | WESLEY | 6 | Youngest Crusher in Star Trek: The Next Generation |
| 40% | TROI | 4 | Counselor Deanna on Star Trek: The Next Generation |
| 40% | DORN | 4 | Michael who played Worf on "Star Trek: The Next Generation" |
| 39% | TROI | 4 | Picard's counselor on Star Trek: The Next Generation |
| 39% | LEONARDNIMOY | 12 | Actor who meets his younger self, played by Zachary Quinto, in the 2009 film "Star Trek": 2 wds. |
| 39% | DATA | 4 | "Star Trek: The Next Generation" android |
| 39% | TROI | 4 | "Star Trek: The Next Generation" counselor |