| 100% | MACKENZIEDAVIS | 14 | "Station Eleven" actress who plays Louise Dalton in 46-Across (2 wds.) |
| 61% | AMANDAPLUMMER | 13 | "Pulp Fiction" actress who plays Louise in "Ratched": 2 wds. |
| 61% | REBECCAROMIJN | 13 | "Ugly Betty" actress who plays Eve Baird in 46-Across (2 wds.) |
| 60% | ISABELSANFORD | 13 | Actress who played Louise on "All in the Family" and 45-Across (2 wds.) |
| 58% | ISABELSANFORD | 13 | Actress who played Louise on 15-Across: 2 wds. |
| 58% | SUSANSARANDON | 13 | Actress who played Louise, one of the title characters on the run in 1991's "Thelma & Louise": 2 wds. |
| 56% | ELLIEKEMPER | 11 | Actress who plays the lead role in 12-/24-Across: 2 wds. |
| 56% | HOLLYHUNTER | 11 | "The Piano" actress who played "Ed" McDunnough in 32-Across: 2 wds. |
| 55% | JULIANNEMOORE | 13 | "Still Alice" actress who plays 19-Across later in life: 2 wds. |
| 54% | REBELWILSON | 11 | "Bridesmaids" actress who played Fat Amy in 14-Across: 2 wds. |
| 54% | JANETLEIGH | 10 | "Psycho" actress who played Rosie DeLeon in 30-Across: 2 wds. |
| 54% | CARRIEFISHER | 12 | "Star Wars" actress who played Carol Peterson in 50-Across: 2 wds. |
| 54% | REGINAHALL | 10 | "Girls Trip" actress who played Brenda Meeks in 17-Across: 2 wds. |
| 53% | BETTEMIDLER | 11 | "Beaches" actress who played witch Winnie Sanderson in 29-/30-Across: 2 wds. |
| 53% | ANYATAYLORJOY | 13 | "Glass" actress who played 19-Across in a 2020 film: 2 wds., hyph. |
| 53% | LEAMICHELE | 10 | Actress who plays 17-Across' girlfriend and was 29-Across' girlfriend in real life: 2 wds. |
| 53% | KATHYNAJIMY | 11 | "Sister Act" actress who played witch Mary Sanderson in 29-/30-Across: 2 wds. |
| 53% | JENNIFERLOPEZ | 13 | "Hustlers" actress who played US marshal Karen Sisco in 23-/35-Across: 2 wds. |
| 53% | DAKOTAJOHNSON | 13 | Actress who will play Anastasia Steele in 18-Across: 2 wds. |
| 53% | SANDRADEE | 9 | Actress who played Gidget in 1959: 2 wds. |
| 53% | MAURATIERNEY | 12 | "The Affair" actress who plays Grace Poe in the Showtime adaptation of 46-Across (2 wds.) |
| 53% | HAYLEYATWELL | 12 | "Agent Carter" actress who plays 18-Across's wife Evelyn in "Christopher Robin": 2 wds. |
| 53% | JULIECHRISTIE | 13 | "Shampoo" actress who played Lara in the 1965 film version of 19-Across: 2 wds. |
| 52% | MAYARUDOLPH | 11 | "Bridesmaids" actress who plays Christine in 32-Across: 2 wds. |
| 52% | MIAWASIKOWSKA | 13 | Actress who played the daughter of 14- and 32-Across in "The Kids Are All Right": 2 wds. |
| 52% | RACHELMCADAMS | 13 | "Doctor Strange" actress who plays the title character's mom in 33-/49-Across: 2 wds. |
| 52% | KRYSTENRITTER | 13 | "Jessica Jones" actress who plays Lucy in the "Echoes" spin-off of 18-Across: 2 wds. |
| 52% | PIPERLAURIE | 11 | "Carrie" actress who played 27-Across's mother in "Children of a Lesser God": 2 wds. |
| 52% | HAYLEYATWELL | 12 | Actress who plays Grace in the new "Mission: Impossible" movie: 2 wds. |
| 52% | JANELLEMONAE | 12 | Actress who played Chiron's maternal figure Teresa in "Moonlight": 2 wds. |