| 100% | SPICE | 5 | "Sugar, ___, and everything nice" (ingredients to concoct the Powerpuff Girls) |
| 56% | SPICE | 5 | "Sugar, ___, and everything nice" (Powerpuff Girls make-up) |
| 43% | SPICE | 5 | "Sugar, ___, and everything nice" |
| 41% | BAGEL | 5 | It might have sugar and spice or everything. Nice! |
| 39% | FOE | 3 | Mojo Jojo, to the Powerpuff Girls |
| 39% | BUBBLES | 7 | Blossom, __ and Buttercup: The Powerpuff Girls |
| 37% | SOROPTIMISTCLUB | 15 | Organization to improve the lives of women and girls |
| 37% | TRIO | 4 | The Powerpuff Girls, e.g. |
| 37% | TRIO | 4 | The Powerpuff Girls, for example |
| 36% | SPICE | 5 | "Sugar and ___ and everything nice" |
| 36% | SPICE | 5 | "Sugar and ___ and everything nice ..." |
| 36% | BLOSSOM | 7 | Leader of the Powerpuff Girls |
| 36% | PPG | 3 | Acronym for the Powerpuff Girls |
| 35% | NICE | 4 | "Sugar, spice, and everything ___" ("Powerpuff Girls" recipe) |
| 35% | MOJOJOJO | 8 | Big-brained monkey baddie from the Powerpuff Girls |
| 35% | MOJO | 4 | ___ Jojo (enemy of the Powerpuff Girls) |
| 35% | SHAMEONYOU | 10 | "That wasn't nice!" and a hint to a trigram hidden in the asterisked answers |
| 35% | KITCHEN | 7 | "Heart of the home," where flames dance and ingredients collide to make a sumptuous meal! |
| 35% | TRIO | 4 | The Powerpuff Girls or the Jonas Brothers, e.g. |
| 34% | TRIOS | 5 | Charlie's Angels, the Powerpuff Girls, etc. |
| 34% | EYES | 4 | Oversized facial feature of the Powerpuff Girls |
| 34% | CHEMICALX | 9 | Mutagen that gave The Powerpuff Girls their superpowers |
| 34% | MOJO | 4 | With 5-Across, archenemy of the Powerpuff Girls |
| 34% | LAB | 3 | Where the Powerpuff Girls were made, for short |
| 34% | SODAMIXER | 9 | Ingredient in some cocktails ... or a hint to the last words in 17-, 23-, 32-, 43- and 48-Across |
| 34% | ISOTONIC | 8 | Word applied to sports drinks that have similar concentrations of salt and sugar as the human body |
| 34% | BUBBLES | 7 | Powerpuff Girl alongside Blossom and Buttercup |
| 33% | FORTYTWO | 8 | The answer to "Life, the Universe and Everything," per Douglas Adams |
| 33% | TRIO | 4 | Charlie's Angels or The Powerpuff Girls, e.g. |
| 33% | CYNICS | 6 | People who know "the price of everything, and the value of nothing," according to an Oscar Wilde play |