| 100% | MASK | 4 | "The ___," 1994 Jim Carrey movie that is based on a comic book series by Dark Horse Comics |
| 51% | MEN | 3 | "___ in Black," movie series starring Will Smith based on the comic book series by Lowell Cunningham |
| 48% | THEWALKINGDEAD | 14 | Dystopian horror TV series that depicts the post-apocalyptic horror and is based on a comic series by Robert Kirkman: 3 wds. |
| 46% | DEADLYCLASS | 11 | 2019 TV series developed by Rick Remender and Miles Orion which is based on a comic book series by Image Comics: 2 wds. |
| 46% | WYNONNAEARP | 11 | 2016 TV series developed by Emily Andras which is based on the comic book series by Beau Smith: 2 wds. |
| 41% | WATCHMEN | 8 | American satirical and dystopian superhero film directed by Zack Snyder which is based on a DC Comics limited series of the same name |
| 40% | RESIDENTALIEN | 13 | Syfy series starring 15-Across, 29-Across, and 36-Across based on a Dark Horse Comics comic book (2 wds.) |
| 40% | ALIENS | 6 | "Cowboys & ___," 2011 Daniel Craig movie that is based on a graphic novel by Scott Mitchell Rosenberg |
| 40% | ROALDDAHL | 9 | Writer of the children's books that the movies directed by 14-, 20-, and 36-Across were based on: 2 wds. |
| 40% | WITCHER | 7 | "The ___," 2019 TV series based on the book series by Andrzej Sapkowski which was adapted into a video game |
| 39% | RUINS | 5 | "Adam ___ Everything," TV show starring Adam Conover that is based on a CollegeHumor web series of the same name |
| 39% | DENNIS | 6 | "___ the Menace," 1993 live-action film starring Mason Gamble that is based on a popular comic strip |
| 39% | CUJO | 4 | 1983 horror movie based on a Stephen King book and featuring a rabid dog that was set largely in one location, the Trenton family home |
| 38% | NOW | 3 | "The Spectacular ___," romantic comedy film which was based on a book of the same name by Tim Tharp |
| 38% | GOAL | 4 | "Next ___ Wins," sports comedy film directed by Taika Waititi that is based on a 2014 documentary of the same name |
| 38% | STREET | 6 | "___ Fighter," 1994 action film starring Kylie Minogue that was based on the eponymous video game series |
| 38% | IRON | 4 | "___ Fist" 2017 TV series created by Scott Buck which is based on a Marvel Comics character |
| 37% | RIVERDALE | 9 | CW series, produced by Greg Berlanti, that's based on the characters of Archie Comics |
| 37% | TOMB | 4 | "___ Raider," comic book series based on the video game that features Lara Croft |
| 37% | HAMELIN | 7 | "The Pied Piper of ___," poem written by Robert Browning that is based on a folktale |
| 37% | DREDD | 5 | "Judge ___" (Sylvester Stallone film based on a comic book series) |
| 37% | THEMIDDLEMAN | 12 | 2008 TV series developed by Javier Grillo-Marxuach which is based on a series by Viper Comics: 2 wds. |
| 37% | THOR | 4 | "___: The Dark World," 2013 superhero film based on a Marvel Comics character that stars Natalie Portman |
| 36% | SWEETBITTER | 11 | American drama TV series starring Ella Purnell which is based on a novel of the same name by Stephanie Danler |
| 36% | OLD | 3 | "Star Wars: Knights of the ___ Republic," monthly comic book series once published by Dark Horse Comics |
| 36% | MALIBUSTACY | 11 | Doll in a 1994 episode of "The Simpsons" that was based on the "Teen Talk" version of 32-Across (2 wds.) |
| 36% | HEX | 3 | "Jonah ___" (2010 movie based on a comic book) |
| 36% | ARK | 3 | "Schindler's ___", original title of the book by Thomas Keneally that "Schindler's List" was based on |
| 36% | BATMANFOREVER | 13 | Comic book adaptation of the 1995 movie based on a DC Comics character: 2 wds. |
| 36% | WALKING | 7 | Hit show based on a comic book, The __ Dead |