| 100% | BIGBANGTHEORY | 13 | "The ___," sitcom created by Chuck Lorre and Bill Prady for CBS whose 12th season premiered on September 24, 2018: 3 wds. |
| 36% | HALFMEN | 7 | "Two and a ___," sitcom created by Chuck Lorre and Lee Aronsohn that aired on CBS: 2 wds. |
| 27% | THEAVENGERS | 11 | Team of superheroes created by Stan Lee and Jack Kirby for Marvel Comics on which the highest-grossing film of 2018 was based: 2 wds. |
| 27% | SHELDON | 7 | "Young ___," comedy series created by Chuck Lorre and Steven Molaro for CBS which is a spin-off prequel to 30a |
| 26% | SUPERFUNNIGHT | 13 | ABC sitcom created by and starring 18-Across: 3 wds. |
| 23% | DARKBLUE | 8 | Color on the spaces for 24- and 42-Across: 2 wds. |
| 22% | PRAYFORME | 9 | 2018 Top 10 hit song by 50-Across and Kendrick Lamar on the "Black Panther" movie soundtrack (3 wds.) |
| 22% | ANNAFARIS | 9 | Actress who played Christy Plunkett on the first seven seasons of the CBS sitcom "Mom": 2 wds. |
| 22% | DIONNEWARWICK | 13 | "Walk On By" singer who was the Mouse on season 3 of "The Masked Singer": 2 wds. |
| 22% | BLUEBLOODS | 10 | Former police drama starring 19-Across and 35-Across that ran for 14 seasons on CBS (2 wds.) |
| 22% | LAURENGROFF | 11 | "Fates and Furies" author whose "Florida" was nominated for the 2018 National Book Award for Fiction (2 wds.) |
| 22% | ROSEANNEBARR | 12 | Former sitcom star who ran for president in 2012 on the Peace and Freedom Party ticket: 2 wds. |
| 21% | BILLWALTON | 10 | NBA player for the Portland Trail Blazers, whose career was ended by a string of foot and ankle injuries: 2 wds. |
| 21% | FBI | 3 | CBS crime drama that premiered on September 25, 2018 |
| 21% | ANDRADAY | 8 | Singer who performed "Stand Up for Something" at the 2018 Oscars, accompanied by Common and various activists: 2 wds. |
| 21% | ROBGRONKOWSKI | 13 | Former Patriots and Buccaneers tight end who was the White Tiger on season 3 of "The Masked Singer": 2 wds. |
| 21% | JOEWEST | 7 | Detective played by 30-Across on "The Flash" for nine seasons (2 wds.) |
| 21% | METYOURMOTHER | 13 | "How I ___" American sitcom created by Craig Thomas and Carter Bays, which stars Neil Patrick Harris: 3 wds. |
| 20% | BRANDONROY | 10 | NBA player for the Portland Trail Blazers, whose career was ended by several in-game knee injuries and lack of cartilage: 2 wds. |
| 20% | MEETTHEPRESS | 12 | Weekly news/interview show hosted by Chuck Todd that is the longest-running program on American television (3 wds.) |
| 20% | ALFIESOLOMONS | 13 | "Peaky Blinders" character, played by Tom Hardy, who ran a distillery and was seen on the show from season 2 till 4: 2 wds. |
| 20% | CAROLBURNETT | 12 | Comedian and actress whose skit show debuted on CBS in September 1967 (2 wds.) |
| 20% | JOHNNYENGLISH | 13 | A comically incompetent spy for "MI7," created as a parody of 50a, and portrayed by Rowan Atkinson in the films by the same name: 2 wds. |
| 20% | BESTOFMYLOVE | 12 | Song by the Emotions that was #3 on Billboard's year-end Hot 100 for 1977: 4 wds. |
| 20% | ANYTHINGGOES | 12 | 1934 show with music and lyrics by 39-Across whose 1987 and 2011 revivals both won the Tony Award for Best Revival of a Musical (2 wds.) |
| 19% | IMET | 4 | "How ___ Your Mother" (sitcom whose final season starts on September 23): 2 wds. |
| 19% | LETSMAKELOVE | 12 | Duet by Faith Hill and Tim McGraw, released in 2000, that won the couple a Grammy for Best Country Collaboration with Vocals: 3 wds. |
| 19% | IRA | 3 | ___ Madison III (writer and podcaster on Season 3 of The Floor) |
| 19% | THEDARKKNIGHT | 13 | 2008 film based on the superhero Batman whose music was composed by Hans Zimmer and James Newton Howard: 3 wds. |
| 19% | CALLOUTMYNAME | 13 | 2018 Top 10 hit song by The Weeknd included on 49-Across (4 wds.) |