| 100% | ONE | 3 | "The ___ and only..." |
| 100% | ONE | 3 | "The ___ and only" |
| 100% | ONE | 3 | "The ___ and only.." |
| 98% | TRUELOVE | 8 | The one and only |
| 95% | PELOSI | 6 | First and only female Speaker of the House |
| 94% | DOLE | 4 | First and only president of the Republic of Hawaii |
| 94% | SELENA | 6 | Singer and Only Murders in the Building actress Gomez |
| 88% | IVAN | 4 | The One and Only ___ (children's book about a gorilla) |
| 88% | ONE | 3 | "The ___ and Only Ivan" (2020 Sam Rockwell film) |
| 87% | YOUNG | 5 | In the saying and song, only the good die this way |
| 86% | FEB | 3 | Only mo. that can start and end on the same day |
| 86% | SCHIRRA | 7 | Only astronaut to fly in the Mercury, Gemini and Apollo programs |
| 86% | SPLIT | 5 | Bowl that leaves only the 7 and 10 pins |
| 85% | AJFOYT | 6 | Only driver to win Indy and Le Mans in the same year |
| 85% | CLAPTON | 7 | Only three-time inductee into the Rock and Roll Hall of Fame |
| 85% | MIMI | 4 | Only character with the same name in both "Rent" and "La Bohème" |
| 84% | BILLYJOEL | 9 | Singer of Only the Good Die Young and Piano Man |
| 84% | ONE | 3 | "The ___ and Only Ivan" (Sam Rockwell film about a gorilla) |
| 83% | ASNER | 5 | Only actor to win a comedy and drama Emmy for the same character |
| 83% | MCENTIRE | 8 | She and Timberlake sang the duet "The Only Promise That Remains" |
| 83% | SAMSMITH | 8 | I'm Not the Only One and Lay Me Down singer |
| 83% | DNA | 3 | Its code uses only the letters A, G, C and T |
| 83% | TURNDOWNANOSCAR | 15 | What 18 and 52 Across were the only performers to do |
| 81% | FEB | 3 | Only mo. that can begin and end on the same day of the week |
| 81% | ADELE | 5 | Only performer to twice sweep the Album, Record and Song of the Year Grammys |
| 81% | ARCHIEGRIFFIN | 13 | Only player to win the 15-Across twice, in 1974 and 1975: 2 wds. |
| 81% | FOSSE | 5 | Only person to win an Oscar, Emmy and Tony in the same year (1973) |
| 81% | DST | 3 | What Ariz. and Hawaii are the only two states not to have |
| 81% | SPLIT | 5 | Arrangement when only the 7 and 10 pins are standing, in bowling |
| 81% | FORTY | 5 | Negative temperature at which Fahrenheit and Celsius intersect, the only such point |