| 100% | CAMEL | 5 | "The ___ Club" (first novel in a David Baldacci political thriller series) |
| 58% | DIVINEJUSTICE | 13 | Fourth novel in a series featuring Oliver Stone and his group of political watchdogs called the Camel Club (2 wds.) |
| 44% | THEFALLEN | 9 | Thriller novel by David Baldacci which was part of "Memory Man" series and became a NYT 2018 Bestseller: 2 wds. |
| 44% | TWILIGHT | 8 | First book in a series of vampire novels by Stephenie Meyer |
| 43% | RABBITRUN | 9 | First in a John Updike novel series |
| 43% | INHERITANCE | 11 | First novel in 39-Across's "The Lost Bride" romance series |
| 42% | DARKOFTHEMOON | 13 | First book in a series of novels by John Sandford featuring 46-Across (4 wds.) |
| 41% | LADIES | 6 | "The No. 1 ___ Detective Agency" (first novel in a mystery series by Alexander McCall Smith) |
| 40% | LADY | 4 | "___ in the Lake" (Apple TV+ series based on a Laura Lippman novel) |
| 40% | THEAWAKENING | 12 | First novel in 39-Across's "The Dragon Heart Legacy" fantasy series (2 wds.) |
| 40% | CASCA | 5 | Roman soldier in a series of novels by Barry Sadler beginning with 1979's The Eternal Mercenary |
| 39% | ANGELS | 6 | __ & Demons, first novel in Robert Langdon series |
| 39% | AIS | 3 | & 13D 1982 novel by Sue Grafton; first in the Kinsey Millhone alphabet mystery series |
| 38% | DEAD | 4 | "___ Until Dark" (first novel in the "Sookie Stackhouse" vampire series by Charlaine Harris) |
| 38% | DEADTHING | 9 | Every __; first novel in Charlie Parker series |
| 38% | ATOB | 4 | First step in a series |
| 38% | OPENER | 6 | First game in a series |
| 38% | ONE | 3 | First number in a series |
| 37% | TIME | 4 | "Only ___ Will Tell," 2011 novel by Jeffrey Archer which is the first in the "Clifton Chronicles" series |
| 37% | ALTEREDCARBON | 13 | Netflix series, based on a cyberpunk novel, set more than 300 years in the future: 2 wds. |
| 37% | PILOT | 5 | First episode in a TV series |
| 37% | KNOT | 4 | "Shopaholic Ties the ___" (third novel in a series by Sophie Kinsella) |
| 37% | IVANA | 5 | Trump with a cameo in "The First Wives Club" |
| 37% | GLINDAOFOZ | 10 | 1920 novel in a series by L Frank Baum |
| 37% | ANTE | 4 | First bet in a summer World Series |
| 37% | DORASPENLOW | 11 | First wife of David Copperfield in a 1850 novel by Charles Dickens |
| 37% | GOT | 3 | First book in the series "A Song of Ice and Fire," familiarly |
| 37% | IVANA | 5 | Trump who had a cameo in “The First Wives Club” |
| 37% | IVANA | 5 | Trump who had a cameo in "The First Wives Club" |