| 100% | LONE | 4 | "The ___ Gunmen" (spin-off of "The X-Files") |
| 95% | LONE | 4 | "The ___ Gunmen" (2001 spin-off of "The X-Files") |
| 66% | MULDER | 6 | __ and Scully, the protagonists of The X-Files |
| 66% | SCULLY | 6 | Mulder and __, leading characters of the X-Files |
| 66% | DUCHOVNY | 8 | David, star of The X-Files and Californication |
| 66% | XENA | 4 | "Hercules" spin-off of the 1990s |
| 63% | ANGEL | 5 | Spin-off of "Buffy the Vampire Slayer" |
| 63% | MEDITERRANEAN | 13 | Bravo spin-off of 15-Across since 2016, set off the coast of Europe |
| 61% | DANA | 4 | First name of Agent Scully in The X-Files |
| 61% | LONE | 4 | The ___ Gunmen (characters on "The X-Files") |
| 60% | DRAGON | 6 | House of the ___ (Game of Thrones spin-off) |
| 60% | ESAI | 4 | Morales of the "Battlestar Galactica" spin-off "Caprica" |
| 60% | ANGEL | 5 | 1999 spin-off of Buffy the Vampire Slayer |
| 60% | PINKY | 5 | "___ and the Brain" (1990s spin-off of "Animaniacs") |
| 60% | DOWNUNDER | 9 | Bravo/Peacock spin-off of 15-Across since 2022, set off the coast of Australia: 2 wds. |
| 59% | ABE | 3 | Actor Vigoda of the "Barney Miller" spin-off "Fish" |
| 59% | MAME | 4 | She "charmed the husk right off of the corn" |
| 59% | GILLIAN | 7 | Anderson of "The X-Files" |
| 59% | YEAGER | 6 | Flier of the X-1 |
| 59% | WOLVERINE | 9 | One of the X-Men |
| 59% | ESPN | 4 | Broadcaster of the X Games |
| 59% | ERASE | 5 | Rub off of the page |
| 59% | STARTREK | 8 | "___: Deep Space Nine," American TV series that is a spin-off of the original |
| 58% | BYTEDANCE | 9 | Company ordered by the Trump Administration to sell or spin off the U.S. operations of TikTok (August, 2020) |
| 58% | DANA | 4 | Agent Scully of "The X-files" |
| 58% | GILLIAN | 7 | Actress Anderson of "The X-Files" |
| 58% | DANA | 4 | Agent ___ Scully of "The X-Files" |
| 58% | JEAN | 4 | ___ Grey (member of the X-Men) |
| 58% | EMMA | 4 | ___ Frost (member of the X-Men) |
| 58% | EMMA | 4 | Ms. Frost of the X-Men |