| 100% | HOUR | 4 | "The ___ I First Believed" (Wally Lamb novel) |
| 49% | SHES | 4 | "__ Come Undone": Wally Lamb novel |
| 43% | CASINO | 6 | The first James Bond novel: "__ Royale" |
| 42% | OPIONEERS | 9 | First novel of the Great Plains trilogy |
| 42% | ISITTRUE | 8 | “Should I believe the rumors?” |
| 41% | REDDRAGON | 9 | The first novel in the Hannibal Lecter saga |
| 41% | JANEEYRE | 8 | Novel with the line "Reader, I married him" |
| 41% | EVE | 3 | The first to hear "Madam, I'm Adam" |
| 41% | JOSEPHINE | 9 | The first wife of French emperor Napoleon I |
| 41% | PLEASE | 6 | First album released by The Beatles, __ Please Me |
| 41% | PICKWICK | 8 | Charles Dickens' first novel, The __ Papers |
| 41% | TRUE | 4 | "I Know This Much Is ___" (HBO miniseries based on a Wally Lamb novel) |
| 41% | KNOW | 4 | "I ___ This Much Is True" (HBO miniseries based on a Wally Lamb novel) |
| 41% | AID | 3 | "Quick, get me the first-__ kit!" |
| 41% | MOBYDICK | 8 | Novel that opens with the line "Call me Ishmael" |
| 41% | YUL | 3 | First name of The King and I actor Brynner |
| 40% | ATE | 3 | "I can't believe I ___ the whole thing" |
| 40% | ATE | 3 | "I can't believe I ___ the whole thing!" |
| 40% | ATE | 3 | 'I can't believe I ___ the whole chicken!' |
| 40% | WHOLE | 5 | "I can't believe I ate the ___ thing" |
| 40% | SHES | 4 | "___ Come Undone" (Wally Lamb novel) |
| 40% | ERE | 3 | "Meet me ___ the first cock crow": Oberon |
| 40% | VECTOR | 6 | Villain in the first Despicable Me film |
| 40% | ERE | 3 | "Meet me ___ the first cock crow" (Shak.) |
| 40% | DUNE | 4 | First winner of the Nebula Award for Best Novel, 1965 |
| 40% | ROYALBOOK | 9 | The __ of Oz, first post-Baum Land of Oz novel |
| 40% | WRIGHT | 6 | Brothers believed to have flown the first plane |
| 40% | MOONSTONE | 9 | Wilkie Collins's The __, the first detective novel |
| 40% | HEAR | 4 | Haruki Murakami's first novel "___ the Wind Sing" |
| 40% | SAINT | 5 | With 6-Across, the first pope, many believe |