| 100% | WITCH | 5 | "The ___ of Portobello," 2006 book by Paulo Coelho that follows the life of Athena |
| 70% | ELEVEN | 6 | "___ Minutes," 2003 novel by Paulo Coelho that follows the life of Maria |
| 56% | GIFT | 4 | "The Supreme ___," 1991 book by Paulo Coelho that was adapted from the works of Henry Drummond |
| 49% | THEPRESTIGE | 11 | 2006 psychological thriller directed by Christopher Nolan that follows the story of rival magicians: 2 wds. |
| 47% | GETON | 5 | "___ Up," 2014 biographical drama film co-produced by Mick Jagger that follows the life of soul singer James Brown: 2 wds. |
| 42% | DETECTIVE | 9 | "___ Conan," manga series that follows the life of a high school investigator |
| 42% | PLL | 3 | Show that follows the lives of Aria, Spencer, Hanna, and Emily: Abbr. |
| 42% | BIOGRAPHY | 9 | The book genre that details the life of a person |
| 41% | RECESS | 6 | Disney's animated series that follows the lives of six elementary school children |
| 40% | INKS | 4 | At least seven of these were used by the monks that created the Book of Kells |
| 40% | BRIDEZILLAS | 11 | Wedding reality show that follows the lives of women engaged to be married, often depicting "difficult" brides |
| 39% | GIRLS | 5 | Lena Dunham's hit comedy-drama that follows the lives of four young women in New York City |
| 39% | EXODUS | 6 | Book of the Bible that follows Genesis |
| 39% | PRACTICE | 8 | "Private ___," medical series following the life of Dr. Addison Montgomery played by Kate Walsh |
| 39% | PARANORMAL | 10 | "___ Activity," 2007 found footage film that follows the lives of a couple with a supernatural presence in their home |
| 39% | PAST | 4 | "Remembrance of Things ___," book by Marcel Proust that holds the world record for longest novel |
| 38% | IDEOLOGY | 8 | The set of beliefs that a culture lives by |
| 38% | STRANGER | 8 | "The ___," novel by Albert Camus published in 1942 which follows the life of a character named Meursault |
| 38% | BEAUTY | 6 | "On ___," 2005 novel by Zadie Smith following the lives of a mixed-race British-American family |
| 38% | SILENTSPRING | 12 | Book by 19-Across that challenged the use of chemical pesticides and sparked environmentalism: 2 wds. |
| 38% | SON | 3 | "The Good ___," 1993 psychological thriller directed by Joseph Ruben that follows the story of a 12-year-old and his psychopathic cousin |
| 38% | IKEA | 4 | Swedish store that's the subject of the book "Leading by Design" |
| 38% | HORIZON | 7 | "Deepwater ___," 2016 film starring Mark Wahlberg that was inspired by the real-life disaster following the Gulf of Mexico oil spill |
| 38% | FIREBIRD | 8 | "The ___," book by Susanna Kearsley that follows dual storylines |
| 38% | THEECHOMAKER | 12 | 2006 novel by 32-Across that won the National Book Award for Fiction (3 wds.) |
| 37% | GAME | 4 | "Master of the ___," 1982 novel by Sidney Sheldon that follows Kate Blackwell's journey |
| 37% | WOMEN | 5 | "Little ___," written by Louisa May Alcott, following the lives of four sisters, whose first part is set during the Christmas period |
| 37% | UNITED | 6 | "___ 93," 2006 film starring Christian Clemenson that was inspired by the real-life disaster following the 9/11 attacks |
| 37% | CAKE | 4 | "___ Boss," reality TV series that follows the operations of Carlo's Bake Shop and is hosted by Buddy Valastro |
| 37% | PET | 3 | "What ___ Should I Get?," 2015 book by Dr. Seuss that chronicles the adventures of Jay and Kay |