| 100% | HOUND | 5 | "The ___ of the Baskervilles," iconic Sherlock Holmes novel with seemingly supernatural elements |
| 51% | HOUND | 5 | "The ___ of the Baskervilles" (Sherlock Holmes novel) |
| 49% | HOUND | 5 | “The ___ of the Baskervilles” (Sherlock Holmes novel) |
| 42% | PERCENTSOLUTION | 15 | ← Sherlock Holmes novel, with "The" |
| 41% | VALLEY | 6 | __ of Fear, the last of the Sherlock Holmes novels |
| 41% | POISOND | 7 | Cause of death in the Sherlock Holmes novel "The Sign of the Four" |
| 40% | FOUR | 4 | "The Sign of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 40% | BASKERVILLES | 12 | "The Hound of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 38% | COAT | 4 | Category of clothing that the Inverness Cape commonly associated with Sherlock Holmes belongs to |
| 38% | COOK | 4 | Peter ___, actor who played Sherlock Holmes in the 1978 British film "The Hound of the Baskervilles" |
| 34% | MORIARTY | 8 | Sherlock Holmes' adversary, the Napoleon of Crime |
| 34% | NIGEL | 5 | Bruce of the Sherlock Holmes films |
| 34% | NATE | 4 | With 20-Down, kiddie-lit counterpart of Sherlock Holmes |
| 33% | SIGNOFFOUR | 10 | The —, 1890 novel by Arthur Conan Doyle featuring Sherlock Holmes |
| 33% | GMAIL | 5 | Element of the Google Apps suite with a spam filter |
| 33% | ENOLA | 5 | Sherlock Holmes's younger sister in a series of YA novels |
| 33% | BASIL | 5 | First name of Sherlock Holmes actor from the 1940s |
| 32% | WOMANINGREEN | 12 | Sherlock Holmes movie, with "The" |
| 32% | FIRE | 4 | I'm one of the classical elements who is associated with heat and dryness |
| 32% | FUTILITY | 8 | Novel by Morgan Robertson that seemingly predicted the sinking of the Titanic |
| 32% | AIR | 3 | One of the four classical elements, along with fire, earth, and water |
| 32% | AER | 3 | One of the four classical elements, along with ignis, aqua and terra |
| 32% | SIR | 3 | ___ Arthur Conan Doyle (title for the creator of Sherlock Holmes) |
| 32% | IRENE | 5 | Adler of the Sherlock Holmes story “A Scandal in Bohemia” |
| 32% | ABELSON | 7 | Philip —, co-discoverer with Edwin McMillan of the element neptunium |
| 32% | AMBUSHING | 9 | Attacking with the element of surprise |
| 32% | WILLIAM | 7 | With 35-Across, author of the classic dystopian novel "Lord of the Flies" |
| 32% | WRINKLEINTIME | 13 | With "A," classic science fantasy novel, and a feature of the theme answers |
| 32% | OPIUMDEN | 8 | *Setting in Sherlock Holmes's "The Man with the Twisted Lip" |
| 31% | BAND | 4 | "The Adventure of the Speckled ___," Sherlock Holmes short story by Arthur Conan Doyle |