| 100% | LOST | 4 | "The ___ World," first book featuring the character of Professor Challenger created by Arthur Conan Doyle |
| 43% | VALLEY | 6 | "The Mystery of the Sasassa ___," first published work by Arthur Conan Doyle |
| 42% | ASTUDYIN | 8 | & 16D First of four Sherlock Holmes novels by Arthur Conan Doyle, published in book form in 1888 |
| 39% | SIGNOFFOUR | 10 | The —, 1890 novel by Arthur Conan Doyle featuring Sherlock Holmes |
| 39% | MORIARTY | 8 | Professor James —, archenemy of Sherlock Holmes in tales by Arthur Conan Doyle |
| 38% | MORIARTY | 8 | Professor James —, arch-enemy of Sherlock Holmes in stories by Arthur Conan Doyle |
| 38% | IRENEADLER | 10 | Holmes character created by Arthur Conan Doyle who may be modeled after Lillie Langtry or Lola Montez |
| 37% | BAND | 4 | "The Adventure of the Speckled ___," Sherlock Holmes short story by Arthur Conan Doyle |
| 37% | FOUR | 4 | "The Sign of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 37% | BASKERVILLES | 12 | "The Hound of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 37% | ELEMENTARY | 10 | CBS detective series based on the characters of Arthur Conan Doyle |
| 36% | FINAL | 5 | & 16A The —, Sherlock Holmes story by Arthur Conan Doyle first published in the Strand Magazine in December 1893 |
| 35% | POLE | 4 | "The Captain of the ___-Star," short story by Arthur Conan Doyle that was published in the Temple Bar |
| 35% | IRENE | 5 | Adler created by Arthur Conan Doyle |
| 35% | BELL | 4 | Joseph ___, surgeon whom Arthur Conan Doyle cites as inspiration for the character of Sherlock Holmes |
| 35% | IRENEADLER | 10 | Opera singer created by Arthur Conan Doyle |
| 35% | SHERLOCK | 8 | ___ Holmes, fictional detective created by Arthur Conan Doyle |
| 34% | SHERLOCKHOLMES | 14 | Fictional detective created by Arthur Conan Doyle: 2 wds. |
| 34% | LANDOFMIST | 10 | The —, 1926 novel by Arthur Conan Doyle |
| 34% | ANNE | 4 | "___ of Green Gables," book by Lucy Maud Montgomery featuring a famous literary character of the same name |
| 33% | STONE | 5 | "Rodney ___," gothic mystery novel by Arthur Conan Doyle that was adapted as "The House of Temperley" |
| 33% | DOCSAVAGE | 9 | Fictional character created by Lester Dent who first appeared in 1933 pulp novel The Man of Bronze |
| 33% | SILVERBLAZE | 11 | 1892 story by Arthur Conan Doyle featuring detective Sherlock Holmes |
| 32% | SHERLOCK | 8 | __ Holmes, character by Sir Arthur Conan Doyle |
| 31% | SIR | 3 | ___ Arthur Conan Doyle (title for the creator of Sherlock Holmes) |
| 31% | NATIVESON | 9 | First Book of the Month Club pick written by a Black American |
| 31% | SHERLOCK | 8 | ___ Holmes, fictional detective created by Arthur Conan Doyle, who you may associate with 20a, 33a, 42a, 9d, and 36d |
| 31% | SHERLOCK | 8 | BBC show based on a series of Arthur Conan Doyle books |
| 31% | FINAL | 5 | "The ___ Problem," Sherlock Holmes short story by Arthur Conan Doyle |