| 100% | THEORY | 6 | "The Big Bang ___," television sitcom in which Neil deGrasse Tyson guest-starred as himself |
| 75% | GUY | 3 | "Family ___," animated sitcom in which Neil deGrasse Tyson guest-starred as himself |
| 65% | BROOKLYN | 8 | "___ Nine-Nine," cop comedy television series in which Neil deGrasse Tyson guest-starred as himself |
| 60% | HORSEMAN | 8 | "BoJack ___," animated television series in which Neil deGrasse Tyson guest-starred as a planetarium narrator |
| 46% | THEORY | 6 | "The Big Bang ___," series in which 45a made an appearance as himself in the episode "The Comet Polarization" |
| 41% | WILWHEATON | 10 | "Star Trek: The Next Generation" actor who guest stars as himself on "The Big Bang Theory" (2 wds.) |
| 39% | HAMM | 4 | Jon ___, "Mad Men" actor who guest starred in the TV show "Family Guy" as himself |
| 38% | DANE | 4 | Eric ___, "Grey's Anatomy" actor who guest starred in the TV show "Family Guy" as himself |
| 38% | LUKE | 4 | ___ Perry, "Beverly Hills, 90210" actor who guest starred in the TV show "Family Guy" as himself |
| 37% | HOT | 3 | "___ in Cleveland," sitcom in which David Spade guest starred as Christopher |
| 37% | ERICKSON | 8 | Leif —, US actor who starred as Big John Cannon in television Western series The High Chaparral from 1967-71 |
| 37% | BARNEY | 6 | & 1D US television sitcom that ran from 1974-82 starring Hal Linden in the title role as a police detective |
| 36% | JUDDHIRSCH | 10 | "Superior Donuts" actor who guest stars as Leonard's dad on "The Big Bang Theory" (2 wds.) |
| 36% | LAURIEMETCALF | 13 | "Lady Bird" actress who guest stars as Sheldon's mom on "The Big Bang Theory" (2 wds.) |
| 35% | MAJORS | 6 | Lee ___, "The Fall Guy" actor who guest starred in the TV show "Family Guy" as himself |
| 34% | JIM | 3 | ___ Carrey, actor who guest starred as the Finger Lakes Guy in "The Office" |
| 34% | HYPERDRIVE | 10 | A science fiction sitcom in which Nick Frost starred as Space Commander Michael Henderson |
| 34% | KUMAILNANJIANI | 14 | "Silicon Valley" actor who starred as a semifictional version of himself in 2017's "The Big Sick": 2 wds. |
| 34% | RODNEY | 6 | Sitcom starring the eponymous stand-up comedian in which Sofia Vergara appeared as Carmen |
| 33% | HENRYWINKLER | 12 | Actor who starred as Fonzie in US television sitcom Happy Days |
| 33% | RHODA | 5 | 1970s US television sitcom starring Valerie Harper in the title role |
| 33% | TONY | 4 | ___ Cavalero, actor who guest stars as Ozzy Osbourne in the 2019 biographical comedy drama "The Dirt" |
| 33% | FATHERTED | 9 | 1990s Channel 4 television sitcom starring Dermot Morgan in the title role |
| 33% | CHELSEAGRAMMAR | 14 | Star of a sitcom in which the First Daughter learns syntax? |
| 32% | ALEX | 4 | ___ Trebek, "Jeopardy!" host who guest starred on an episode in the '80s sitcom "Cheers" |
| 32% | SAVAGE | 6 | Fred —, actor who starred as Kevin Arnold in US television series The Wonder Years |
| 32% | MARTINSHEEN | 11 | Actor who starred as Jed Bartlet in US television drama series The West Wing |
| 32% | SHEEN | 5 | Martin —, actor who starred as Jed Bartlet in US television series The West Wing |