| 100% | JIMPARSONS | 10 | "The Big Bang Theory" actor who narrates 44-Across (2 wds.) |
| 78% | JIMPARSONS | 10 | "The Big Bang Theory" actor who played Michael in "The Boys in the Band": 2 wds. |
| 69% | JIMPARSONS | 10 | "The Big Bang Theory" actor who was nominated for an Emmy Award for "Hollywood" (2 wds.) |
| 66% | JIMPARSONS | 10 | Actor who portrayed Sheldon Cooper in "The Big Bang Theory," and is the narrator in "Young Sheldon": 2 wds. |
| 63% | JIMPARSONS | 10 | Actor who plays Sheldon on "The Big Bang Theory" (2 wds.) |
| 63% | JOHNNYGALECKI | 13 | Actor who plays Leonard on "The Big Bang Theory" (2 wds.) |
| 62% | MAYIMBIALIK | 11 | "The Big Bang Theory" actress who earned a doctorate in neuroscience from 33-Down: 2 wds. |
| 61% | SHELDONCOOPER | 13 | "The Big Bang Theory" character with the catchphrase "Bazinga!": 2 wds. |
| 60% | ADAMWEST | 8 | Batman actor from the 1960s who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 60% | CHUCKLORRE | 10 | Creator of "Two and a Half Men" and "The Big Bang Theory," who is also the co-creator of CBS's new show "Young Sheldon": 2 wds. |
| 59% | PATTONOSWALT | 12 | "The King of Queens" actor who narrates 18-Across as the present-day adult Adam: 2 wds. |
| 59% | JEFFREYWRIGHT | 13 | "Westworld" actor who narrates "What If ...?" as the Watcher: 2 wds. |
| 58% | WILWHEATON | 10 | "Star Trek: The Next Generation" actor who guest stars as himself on "The Big Bang Theory" (2 wds.) |
| 57% | DONCHEADLE | 10 | Emmy-nominated actor who narrates the 2021 reboot of 32-Across (2 wds.) |
| 56% | MAYIMBIALIK | 11 | Former "Blossom" and "The Big Bang Theory" star who co-hosts "Jeopardy!" (2 wds,) |
| 56% | JIMPARSONS | 10 | Star of "The Big Bang Theory": 2 wds. |
| 55% | KALEYCUOCO | 10 | "The Big Bang Theory" actress who says "Every trip is a big deal" in Priceline.com commercials (2 wds.) |
| 55% | DONCHEADLE | 10 | "House of Lies" actor who narrates the 2021 version of 36-Across as the grown version of the 12-year-old lead character: 2 wds. |
| 55% | TOMHIDDLESTON | 13 | "The Avengers" actor who starred in 44-Across: 2 wds. |
| 55% | JEREMYIRONS | 11 | "Dead Ringers" actor who narrated the scientific documentaries "The Last Lions" and "Life on Fire": 2 wds. |
| 54% | MORGANFREEMAN | 13 | "Unforgiven" actor who narrated the scientific documentaries "March of the Penguins" and "Island of Lemurs: Madagascar": 2 wds. |
| 54% | YOUNGSHELDON | 12 | "The Big Bang Theory" prequel starring 13-Across and 27-Across (2 wds.) |
| 53% | SHELDONCOOPER | 13 | Geeky character played by Jim Parsons on "The Big Bang Theory": 2 wds. |
| 53% | TOMHANKS | 8 | Actor who plays Josh Baskin in the movie "Big": 2 wds. |
| 53% | YOUNGSHELDON | 12 | "The Big Bang Theory" prequel whose theme song was written by 41-Across (2 wds.) |
| 53% | YOUNGSHELDON | 12 | "The Big Bang Theory" prequel about one of the scientists as a boy (2 wds.) |
| 53% | KALEYCUOCO | 10 | Actress who plays Penny on "The Big Bang Theory" (2 wds.) |
| 53% | ALECBALDWIN | 11 | "It's Complicated" actor who narrated the scientific documentaries "Journey to the Edge of the Universe" and "Frozen Planet": 2 wds. |
| 52% | JONHAMM | 7 | "Mad Men" actor who appeared on the reality dating show "The Big Date" in 1996: 2 wds. |
| 52% | STEVECARELL | 11 | "The Big Short" actor who played the title boy's father in "Beautiful Boy": 2 wds. |