| 100% | KALEYCUOCO | 10 | "The Big Bang Theory" actress who says "Every trip is a big deal" in Priceline.com commercials (2 wds.) |
| 55% | MAYIMBIALIK | 11 | "The Big Bang Theory" actress who earned a doctorate in neuroscience from 33-Down: 2 wds. |
| 50% | JIMPARSONS | 10 | Actor who portrayed Sheldon Cooper in "The Big Bang Theory," and is the narrator in "Young Sheldon": 2 wds. |
| 48% | CHUCKLORRE | 10 | Creator of "Two and a Half Men" and "The Big Bang Theory," who is also the co-creator of CBS's new show "Young Sheldon": 2 wds. |
| 47% | JIMPARSONS | 10 | "The Big Bang Theory" actor who played Michael in "The Boys in the Band": 2 wds. |
| 47% | EMMATHOMPSON | 12 | Actress who plays the protagonist in "Nanny McPhee and the Big Bang," which is based on the "Nurse Matilda" books: 2 wds. |
| 46% | MAYIMBIALIK | 11 | Actress who played young C.C. Bloom in the 1988 film "Beaches" and Amy Farrah Fowler on "The Big Bang Theory" in 2019: 2 wds. |
| 44% | ADAMWEST | 8 | Batman actor from the 1960s who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 43% | JULIEHAGERTY | 12 | Actress who says "There's no reason to become alarmed ... By the way, is there anyone on board who knows how to fly a plane?" in "Airplane!" (2 wds.) |
| 43% | MAGGIESMITH | 11 | Actress in the Harry Potter movies who was royally dubbed a dame in 1990: 2 wds. |
| 43% | MAYIM | 5 | "The Big Bang Theory" actress __ Bialik who is also a scheduled 2021 "Jeopardy!" guest host |
| 43% | GERALDINEPAGE | 13 | "The Trip to Bountiful" actress who was the voice of villainous Madame Medusa in Disney's "The Rescuers": 2 wds. |
| 42% | EDDIEREDMAYNE | 13 | "The Theory of Everything" actor who was nominated for a 2024 Tony for playing the Emcee in "Cabaret": 2 wds. |
| 42% | AMYPOEHLER | 10 | Actress who played the role of Leslie Knope in "Parks and Recreation", a role she is best-known for: 2 wds. |
| 42% | STEVEWOZNIAK | 12 | Co-founder of Apple and noted philanthropist who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 41% | MAYIM | 5 | ___ Bialik, Emmy-nominated actress best known for her role in "The Big Bang Theory" who has a degree in Neuroscience |
| 41% | MEGANMULLALLY | 13 | "Will & Grace" actress who appeared in a 1983 McDonald's commercial: 2 wds. |
| 41% | JONIMITCHELL | 12 | "Big Yellow Taxi" singer who was made a Companion of the Order of Canada in 2002: 2 wds. |
| 41% | KARYNPARSONS | 12 | Actress who played the snobbish cousin of 17-Across in "The Fresh Prince of Bel-Air," which is rumored to be getting a reunion: 2 wds. |
| 41% | ELONMUSK | 8 | CEO of SpaceX and product architect of Tesla who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 40% | BILLYBUSH | 9 | Former TV star who's contrite for his role in the "Access Hollywood" tape scandal, saying "I'm grateful to be a more conscientious person now": 2 wds. |
| 40% | JIMPARSONS | 10 | "The Big Bang Theory" actor who was nominated for an Emmy Award for "Hollywood" (2 wds.) |
| 40% | ELTONJOHN | 9 | "Candle in the Wind" singer who said of his upcoming farewell tour, "It's a way of going out with a bang": 2 wds. |
| 40% | MINDYKALING | 11 | "The Office" actress who was honored with a star on the Hollywood Walk of Fame in 2023 (2 wds.) |
| 40% | DREWBARRYMORE | 13 | American singer SZA's song which is titled after a "Charlie's Angels" actress who also makes a cameo in the music video: 2 wds. |
| 40% | JESSEPINKMAN | 12 | Character played by Aaron Paul in "Breaking Bad", who was a crystal meth dealer and worked with the character played by 30-Across: 2 wds. |
| 39% | KRISTENBELL | 11 | Actress who is the narrator in "Gossip Girl": 2 wds. |
| 39% | NIAVARDALOS | 11 | Actress who plays a bride-to-be in "My Big Fat Greek Wedding" (2 wds.) |
| 39% | KATHYBATES | 10 | Actress who plays a marijuana dispensary owner in the new Netflix comedy "Disjointed": 2 wds. |
| 39% | KALEYCUOCO | 10 | Actress who plays Penny on "The Big Bang Theory" (2 wds.) |