| 100% | LAURIEMETCALF | 13 | "The Big Bang Theory" actress whose daughter portrays her character's younger self on "Young Sheldon": 2 wds. |
| 50% | LAURIEMETCALF | 13 | Actress whose real-life daughter played a younger version of her character on "Roseanne": 2 wds. |
| 48% | LAURIEMETCALF | 13 | "The Conners" actress who played Sheldon's mother on "The Big Bang Theory" (2 wds.) |
| 48% | MAYIMBIALIK | 11 | Actress who played young C.C. Bloom in the 1988 film "Beaches" and Amy Farrah Fowler on "The Big Bang Theory" in 2019: 2 wds. |
| 47% | LAURIEMETCALF | 13 | "Lady Bird" actress who guest stars as Sheldon's mom on "The Big Bang Theory" (2 wds.) |
| 47% | JIMPARSONS | 10 | Actor who portrayed Sheldon Cooper in "The Big Bang Theory," and is the narrator in "Young Sheldon": 2 wds. |
| 44% | SUSANSARANDON | 13 | Actress whose real-life daughter played a younger version of her character in "Dead Man Walking": 2 wds. |
| 44% | KATEBECKINSALE | 14 | Actress whose real-life daughter played a younger version of her character in "Underworld: Evolution": 2 wds. |
| 43% | SHELDONCOOPER | 13 | Geeky character played by Jim Parsons on "The Big Bang Theory": 2 wds. |
| 42% | MAYIMBIALIK | 11 | She plays Dr. Amy Farrah Fowler—a neurobiologist—on CBS's "The Big Bang Theory": 2 wds. |
| 42% | KATEYSAGAL | 10 | "Sons of Anarchy" actress who played Penny's mother on "The Big Bang Theory" (2 wds.) |
| 41% | KALEYCUOCO | 10 | Actress who plays Penny on "The Big Bang Theory" (2 wds.) |
| 41% | CHUCKLORRE | 10 | Creator of "Two and a Half Men" and "The Big Bang Theory," who is also the co-creator of CBS's new show "Young Sheldon": 2 wds. |
| 41% | SHELDONCOOPER | 13 | "The Big Bang Theory" character with the catchphrase "Bazinga!": 2 wds. |
| 41% | JIMPARSONS | 10 | Actor who plays Sheldon on "The Big Bang Theory" (2 wds.) |
| 39% | RAJ | 3 | Kunal Nayyar's character on The Big Bang Theory |
| 39% | ADAMWEST | 8 | Batman actor from the 1960s who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 38% | DIANARIGG | 9 | "Game of Thrones" actress whose "On Her Majesty's Secret Service" character is the second to marry 16-Across (2 wds.) |
| 37% | MAYIMBIALIK | 11 | "The Big Bang Theory" actress who earned a doctorate in neuroscience from 33-Down: 2 wds. |
| 37% | EMMATHOMPSON | 12 | Actress who plays the protagonist in "Nanny McPhee and the Big Bang," which is based on the "Nurse Matilda" books: 2 wds. |
| 37% | ARIELWINTER | 11 | Actress who plays Alex Dunphy, Phil and Claire's younger daughter, on "Modern Family": 2 wds |
| 37% | AUBREYPLAZA | 11 | Actress who meets her younger self played by Maisy Stella in the 2024 film "My Old Ass": 2 wds. |
| 37% | AMY | 3 | Sheldon's girlfriend on "The Big Bang Theory" |
| 37% | LEONARD | 7 | Sheldon's buddy on "The Big Bang Theory" |
| 37% | AMY | 3 | Sheldon's wife on "The Big Bang Theory" |
| 37% | AMY | 3 | Sheldon's fiancée on "The Big Bang Theory" |
| 36% | PARSONS | 7 | Jim who plays Sheldon on The Big Bang Theory |
| 36% | BAZINGA | 7 | Sheldon Cooper's catchphrase on "The Big Bang Theory" |
| 36% | WILWHEATON | 10 | "Star Trek: The Next Generation" actor who guest stars as himself on "The Big Bang Theory" (2 wds.) |
| 36% | JUDDHIRSCH | 10 | "Superior Donuts" actor who guest stars as Leonard's dad on "The Big Bang Theory" (2 wds.) |