| 100% | LORRE | 5 | "The Big Bang Theory" and "Young Sheldon" co-creator Chuck |
| 69% | CHUCKLORRE | 10 | Creator of "Two and a Half Men" and "The Big Bang Theory," who is also the co-creator of CBS's new show "Young Sheldon": 2 wds. |
| 68% | LORRE | 5 | "The Big Bang Theory" co-creator Chuck |
| 62% | LORRE | 5 | "The Big Bang Theory" creator Chuck |
| 62% | LORRE | 5 | Chuck who co-created "The Big Bang Theory" and "Two and a Half Men" |
| 60% | BIALIK | 6 | The Big Bang Theory and Blossom star Mayim |
| 60% | RAJ | 3 | "The Big Bang Theory" chum of Sheldon and Leonard |
| 59% | RAJ | 3 | "The Big Bang Theory" pal of Sheldon, Leonard, and Howard |
| 59% | SHELDON | 7 | The Big Bang Theory spin-off, Young __ |
| 57% | LORRE | 5 | Chuck who created "The Big Bang Theory" and "Mom" |
| 56% | JIMPARSONS | 10 | Actor who portrayed Sheldon Cooper in "The Big Bang Theory," and is the narrator in "Young Sheldon": 2 wds. |
| 55% | LAURIEMETCALF | 13 | "The Big Bang Theory" actress whose daughter portrays her character's younger self on "Young Sheldon": 2 wds. |
| 54% | LORRE | 5 | Chuck ___, creator of "The Big Bang Theory" |
| 52% | YOUNG | 5 | "The Big Bang Theory" spinoff "___ Sheldon" |
| 52% | LORRE | 5 | Chuck who co-created "Two and a Half Men" and "The Big Bang Theory" |
| 52% | LORRE | 5 | Chuck ___, cocreator of "The Big Bang Theory" and "Two and a Half Men" |
| 51% | TAKEI | 5 | "Star Trek" actor George who has had cameos on "The Big Bang Theory" and "King of the Nerds" |
| 51% | YOUNG | 5 | "The Big Bang Theory" prequel series "___ Sheldon" |
| 50% | AMY | 3 | "The Big Bang Theory" chum of Bernadette and Penny |
| 50% | MAYIMBIALIK | 11 | Former "Blossom" and "The Big Bang Theory" star who co-hosts "Jeopardy!" (2 wds,) |
| 50% | RAJ | 3 | Pal of Sheldon and Leonard on "The Big Bang Theory" |
| 49% | BAZINGA | 7 | The Big Bang Theory catchword |
| 49% | NERD | 4 | The Big Bang Theory stereotype |
| 49% | BAZINGA | 7 | Sheldon word for "gotcha" in The Big Bang Theory |
| 49% | MAYIM | 5 | The Big Bang Theory actress Bialik |
| 49% | PARSONS | 7 | Jim who plays Sheldon on The Big Bang Theory |
| 48% | CHANGE | 6 | "The ___ Constant," episode of "The Big Bang Theory" where Sheldon and Amy wait to hear if they've won the Nobel Prize |
| 48% | YOUNGSHELDON | 12 | "The Big Bang Theory" prequel starring 13-Across and 27-Across (2 wds.) |
| 48% | YLEM | 4 | Matter in the Big Bang theory |
| 48% | RAJ | 3 | Koothrappali of The Big Bang Theory |