| 100% | RAJ | 3 | "The Big Bang Theory" character who was born in New Delhi |
| 64% | RAJ | 3 | "The Big Bang Theory" astrophysicist born in New Delhi |
| 53% | KALEYCUOCO | 10 | "The Big Bang Theory" actress who says "Every trip is a big deal" in Priceline.com commercials (2 wds.) |
| 53% | CHUCKLORRE | 10 | Creator of "Two and a Half Men" and "The Big Bang Theory," who is also the co-creator of CBS's new show "Young Sheldon": 2 wds. |
| 53% | PENNY | 5 | The only major character in "The Big Bang Theory" whose last name was never revealed |
| 52% | RAJ | 3 | Only "The Big Bang Theory" friend who is unmarried when the series ends |
| 52% | APU | 3 | "The Simpsons" character who was born in Rahmatpur |
| 51% | SHELDON | 7 | Who Amy marries in The Big Bang Theory |
| 50% | JIMPARSONS | 10 | "The Big Bang Theory" actor who played Michael in "The Boys in the Band": 2 wds. |
| 50% | RAJ | 3 | "The Big Bang Theory" character whose last name is Koothrappali |
| 49% | WIL | 3 | Wheaton who starred in The Big Bang Theory |
| 49% | NERDY | 5 | Like most characters in The Big Bang Theory |
| 49% | JIMPARSONS | 10 | Actor who portrayed Sheldon Cooper in "The Big Bang Theory," and is the narrator in "Young Sheldon": 2 wds. |
| 48% | BIALIK | 6 | Mayim who played Amy in The Big Bang Theory |
| 47% | JIMPARSONS | 10 | "The Big Bang Theory" actor who was nominated for an Emmy Award for "Hollywood" (2 wds.) |
| 47% | ANTHONYRAMOS | 12 | "A Star Is Born" actor who plays Usnavi, the lead character in 18-Across: 2 wds. |
| 47% | MAYIM | 5 | "The Big Bang Theory" actress __ Bialik who is also a scheduled 2021 "Jeopardy!" guest host |
| 47% | MELANIELYNSKEY | 14 | "Yellowjackets" actress who was born in New Zealand in 1977: 2 wds. |
| 46% | KANE | 4 | Film title character who says, "If the headline is big enough, it makes the news big enough" |
| 46% | MAYIMBIALIK | 11 | "The Big Bang Theory" actress who earned a doctorate in neuroscience from 33-Down: 2 wds. |
| 46% | COOPER | 6 | Sheldon ___, from "The Big Bang Theory" reminds you this New Year that "banks shouldn't be trusted because ATMs may lead the robot uprising" |
| 46% | TAIKAWAITITI | 12 | "Jojo Rabbit" director who was born in New Zealand in 1975: 2 wds. |
| 46% | RUSSELLCROWE | 12 | "A Beautiful Mind" actor who was born in New Zealand in 1964: 2 wds. |
| 45% | SHELDONCOOPER | 13 | "The Big Bang Theory" character with the catchphrase "Bazinga!": 2 wds. |
| 45% | GEEKS | 5 | Many characters in "The Big Bang Theory" |
| 45% | NERDS | 5 | Like most of the characters in "The Big Bang Theory" |
| 44% | OSAKA | 5 | Tennis star Naomi who was born in the city of 3-Down |
| 44% | YLEM | 4 | Matter in the Big Bang theory |
| 44% | RAJ | 3 | "The Big Bang Theory" character |
| 44% | LEONARD | 7 | "The Big Bang Theory" character |