| 100% | ALCOHOL | 7 | "The cause of, and solution to, all of life's problems," per Homer Simpson |
| 42% | NED | 3 | First name of the man who lives next to Homer and Marge |
| 40% | AFRICA | 6 | Home to roughly seventeen per cent of the world’s population |
| 40% | ASIA | 4 | Home to the Taj Mahal and the Great Wall of China |
| 39% | PANACEA | 7 | Answer to all of one's problems |
| 39% | NFL | 3 | Org. that's home to the ends of 20-, 32-, 41- and 52-Across |
| 38% | OHIO | 4 | State that's home to the Rock and Roll Hall of Fame |
| 38% | EUREKA | 6 | Uttered by Archimedes and the solution to problems |
| 38% | MAKESWAVES | 10 | Causes a ruckus, and what the end of each answer to the starred clues does |
| 38% | CLEVELAND | 9 | Ohio city that's home to the Rock and Roll Hall of Fame |
| 37% | EVERGREENTERRACE | 16 | Home of the Simpson and Flanders households |
| 37% | JOCELYNALO | 10 | Softball player who won two championships with the University of Oklahoma and who is both the NCAA's all-time home run leader and the only player to record three 30-home run seasons (2 wds.) |
| 37% | NASHVILLE | 9 | Tennessee city that's home to the Country Music Hall of Fame and Museum |
| 37% | TIMBUKTU | 8 | City in Mali and home to the University of Sankore |
| 37% | OHIO | 4 | Home to both the Rock and Roll and Pro Football Halls of Fame |
| 37% | PRIMEREALESTATE | 15 | Asset that's all about "location, location, location" ... with a hint to the starts of 21-, 26- and 49-Across |
| 36% | HBOGO | 5 | Service that would give you access to all of The Sopranos and Sex and the City |
| 36% | SCIENCE | 7 | "The great antidote to the poison of enthusiasm and superstition," per Adam Smith |
| 36% | WACO | 4 | Home to the Texas Ranger Hall of Fame and Museum |
| 36% | HOPE | 4 | The feeling of "being able to see that there is light despite all of the darkness," per Desmond Tutu |
| 36% | SALTLAKECITY | 12 | Home of the Utah Jazz, and the location of the 2023 NBA All-Star Weekend (3 wds.) |
| 36% | ADAM | 4 | He "gave names to all cattle, and to the fowl of the air" |
| 36% | EDEN | 4 | Biblical garden home to the tree of the knowledge of good and evil |
| 36% | ROME | 4 | Capital city of Italy and home to the Colosseum |
| 36% | SOROPTIMISTCLUB | 15 | Organization to improve the lives of women and girls |
| 35% | DAN | 3 | Actor Castellaneta who provides the voices of Homer, Barney, and Krusty on "The Simpsons" |
| 35% | FORTYTWO | 8 | Number that’s the answer to the Ultimate Question of Life, the Universe and Everything, in “The Hitchhiker’s Guide to the Galaxy” |
| 35% | OREGON | 6 | State revealed to be home of The Simpsons in 2012 |
| 35% | SURVIVES | 8 | Gets out of danger and lives to tell the tale |
| 35% | ABC | 3 | Industrial area of Sao Paulo, Brazil, that's home to many auto manufacturers and is known as the "___ Region" |