| 100% | MERYLSTREEP | 11 | "The Devil Wears Prada" actress who plays a struggling actress on "Only Murders in the Building" (2 wds.) |
| 68% | JESSEWILLIAMS | 13 | "Grey's Anatomy" actor who plays a camera operator on "Only Murders in the Building" (2 wds.) |
| 59% | STEVEMARTIN | 11 | "Only Murders in the Building" actor who plays a character based on Cyrano de Bergerac in the film "Roxanne" (2 wds.) |
| 59% | TINAFEY | 7 | "30 Rock" actress who plays Cinda on "Only Murders in the Building" (2 wds.) |
| 59% | AMYRYAN | 7 | "Gone Baby Gone" actress who plays Jan on "Only Murders in the Building" (2 wds.) |
| 59% | INGRIDBERGMAN | 13 | "Casablanca" actress who played a Swedish missionary in "Murder on the Orient Express": 2 wds. |
| 58% | SELENAGOMEZ | 11 | "Wizards of Waverly Place" actress who plays Mabel on "Only Murders in the Building" (2 wds.) |
| 58% | SELENAGOMEZ | 11 | "Only Murders in the Building" actress who received a kidney transplant in 2017: 2 wds. |
| 57% | MARTINSHORT | 11 | "Three Amigos" actor who plays a Broadway director/true crime podcaster on "Only Murders in the Building" (2 wds.) |
| 53% | HELENMIRREN | 11 | "The Queen" actress who plays a retired intelligence agent in "The Thursday Murder Club": 2 wds. |
| 52% | SELENAGOMEZ | 11 | 18-Across and 30-Across singer who plays Mabel Mora on "Only Murders in the Building" (2 wds.) |
| 52% | UZOADUBA | 8 | "In Treatment" actress who plays a detective on the Netflix series "The Residence": 2 wds. |
| 51% | STEVEMARTIN | 11 | "Dirty Rotten Scoundrels" actor who plays Charles on "Only Murders in the Building" (2 wds.) |
| 51% | OLIVIACOOKE | 11 | "Ready Player One" actress who plays the pregnant girlfriend of a murdered man in 31-Across (2 wds.) |
| 51% | LAURENBACALL | 12 | "Key Largo" actress who played an American widow in "Murder on the Orient Express": 2 wds. |
| 51% | GRACEKELLY | 10 | Actress who played a socialite in Hitchcock's "Dial M for Murder": 2 wds. |
| 51% | JANELYNCH | 9 | Former host of "Hollywood Game Night" who plays Sazz on "Only Murders in the Building" (2 wds.) |
| 51% | AMY | 3 | Actress Ryan who plays Jan on "Only Murders in the Building" |
| 50% | SANDRABULLOCK | 13 | "Ocean's 8" actress who plays a novelist kidnapped in the jungle in "The Lost City": 2 wds. |
| 50% | JEANHAGEN | 9 | "The Danny Thomas Show" costar who played a vain actress in "Singin' in the Rain": 2 wds. |
| 50% | JEANSTAPLETON | 13 | Actress who played mom Edith Bunker on "All in the Family": 2 wds. |
| 50% | MARLEEMATLIN | 12 | "CODA" actress who played a deaf employee at the school in "Children of a Lesser God": 2 wds. |
| 50% | ANNETTEBENING | 13 | "American Beauty" actress who plays Euphemia in the upcoming movie "Death on the Nile": 2 wds. |
| 50% | ZOESALDANA | 10 | "Avatar" actress who played a pirate in the first "Pirates of the Caribbean" film: 2 wds. |
| 49% | HILARYSWANK | 11 | "Million Dollar Baby" actress who plays a journalist whose son was murdered in 31-Across (2 wds.) |
| 49% | STEVEMARTIN | 11 | "Only Murders in the Building" actor who shares his surname with a guitar maker (2 wds.) |
| 49% | KATHYBATES | 10 | Actress who plays a marijuana dispensary owner in the new Netflix comedy "Disjointed": 2 wds. |
| 49% | WINONARYDER | 11 | Actress who plays a grandmother who tells the story of why it always snows on Christmas in Lutz, Florida, in "Edward Scissorhands" (2 wds.) |
| 49% | MERYLSTREEP | 11 | "Into the Woods" actress who plays a feminist in 42-Across: 2 wds. |
| 49% | PAUL | 4 | With 50-Across, "Ant-Man" actor who plays a murdered Hollywood actor on "Only Murders in the Building" |