| 100% | ETERNITY | 8 | "The End of ___," 1955 sci-fi novel by Isaac Asimov that was shortlisted for the Hugo Award for Best Novel |
| 54% | NAKEDSUN | 8 | "The ___," 1957 sci-fi novel by Isaac Asimov that was adapted into an episode of the TV series "Out of the Unknown": 2 wds. |
| 46% | ARRIVAL | 7 | Sci-fi film by Denis Villeneuve that won the 2017 Hugo Award for Best Dramatic Presentation |
| 46% | GRAVITY | 7 | Sci-fi film by Alfonso Cuaron that won the 2014 Hugo Award for Best Dramatic Presentation |
| 45% | AMERICANGODS | 12 | Novel by 39-Across that won the Hugo Award for Best Novel and the Nebula Award for Best Novel (2 wds.) |
| 42% | SALEMS | 6 | "___ Lot," 1975 novel by Stephen King that was nominated for the World Fantasy Award |
| 42% | TESH | 4 | Emily ___, winner of the 2024 Hugo Award for Best Novel |
| 41% | LANE | 4 | "The Ocean at the End of the ___," 2013 Neil Gaiman novel featuring themes of magical realism that was nominated for a Nebula Award |
| 41% | SPINNINGSILVER | 14 | 2019 Locus Award for Best Fantasy Novel winner by 27-Across that's loosely based on the tale of "Rumpelstiltskin" (2 wds.) |
| 41% | MAN | 3 | "The Bicentennial ___," 1976 sci-fi novelette by Isaac Asimov that was adapted into a 1999 film starring Robin Williams |
| 40% | ROSE | 4 | "The Name of the ___," best-selling novel by Umberto Eco that was originally written in Italian |
| 40% | STATEOFWONDER | 13 | 2011 novel by 28-Across that was shortlisted for the Orange Prize for Fiction (3 wds.) |
| 40% | GIANT | 5 | "The Buried ___," 2015 fantasy novel by Kazuo Ishiguro which was nominated for the 2016 World Fantasy Award for best novel |
| 40% | HAMMER | 6 | "The ___ of God," 1993 sci-fi novel by Arthur C. Clarke that is set in the year 2109 |
| 40% | ONTHEROADAGAIN | 14 | Song by 30-Across/33-Across that won a Grammy Award for Best Country Song and was inducted into the Grammy Hall of Fame (4 wds.) |
| 40% | REAL | 4 | With 27-Across, novel by 42-Across that was shortlisted for the 2020 Booker Prize |
| 40% | HELICOPTER | 10 | Invention whose successful model was made by Igor Sikorsky that was inspired by the sci-fi novel "Clipper of the Clouds" by Jules Verne |
| 40% | SONGS | 5 | "The ___ of Distant Earth," 1986 sci-fi novel by Arthur C. Clarke that is set in the early 3800s |
| 39% | TRON | 4 | Pioneering sci-fi film that was snubbed for the Best Visual Effects Oscar for its use of computers |
| 39% | IROBOT | 6 | 1950 sci-fi fixup novel by Isaac Asimov that shares its title with a 2004 film starring Will Smith: 2 wds. |
| 39% | WEB | 3 | World Wide ___, invention by Tim Berners-Lee that was mentioned in the sci-fi novel "Dial F for Frankenstein" by Arthur C. Clarke |
| 38% | GREENGAGE | 9 | "The Enlightenment of the ___ Tree," novel by Shokoofeh Azar which was shortlisted for the International Booker Prize 2020 |
| 38% | ISLANDS | 7 | "___ in the Sky," 1952 sci-fi novel by Arthur C. Clarke that is set in the later half of the 21st century |
| 38% | KILLINGFLOOR | 12 | Debut novel by 25-Across that was the basis for the first season of "Reacher" (2 wds.) |
| 38% | TYLL | 4 | Novel by Daniel Kehlmann which was shortlisted for the International Booker Prize 2020 |
| 38% | WORLDS | 6 | Sci-fi novel by H.G. Wells: The War of the __ |
| 37% | SPRINGS | 7 | "Silver ___," 1976 song by Fleetwood Mac that was nominated for a Grammy Award for Best Pop Performance |
| 37% | NEXT | 4 | "Thank U, ___," number-one hit album by Ariana Grande that was nominated for Album of the Year at the 62nd Grammy Awards |
| 37% | NEEDTOKNOW | 10 | Hit single by 50-Across that was nominated for Best Melodic Rap Performance at the 2022 Grammy Awards (3 wds.) |
| 37% | MEMORY | 6 | "The ___ Police," novel by Yoko Ogawa which was shortlisted for the International Booker Prize 2020 |