| 100% | HONESTY | 7 | "The first chapter in the book of wisdom," to Jefferson |
| 76% | WISDOM | 6 | "Honesty is the first chapter in the book of ___": Thomas Jefferson |
| 56% | ADAM | 4 | First human in the Book of Genesis |
| 54% | EDEN | 4 | Humans' first home in the Book of Genesis |
| 53% | EVE | 3 | First woman mentioned in the Book of Genesis |
| 52% | RLSTINE | 7 | Author referred to as "Stephen King of children's literature" who wrote the first book of the Goosebumps series in 1992 |
| 52% | LIONS | 5 | Threats to Daniel, in the Book of Daniel |
| 51% | AISFORALIBI | 11 | Title of the first book in the 17-Across series |
| 49% | PROVOLONE | 9 | In favor of the first book?: Abbr. |
| 48% | BREWER | 6 | Margaret, first woman in the US Marine Corps to reach the rank of general (1978) |
| 48% | DEADHOUSE | 9 | "Welcome to ___," the first book in the original Goosebumps series by R.L. Stine: 2 wds. |
| 48% | DOG | 3 | President Trump is the first president in over 100 years not to have one of these |
| 48% | WIT | 3 | "___ and wisdom" (phrase in the title of a book of quotes, maybe) |
| 47% | LADYNANCYASTOR | 14 | First woman to sit in the British House of Commons |
| 47% | EDEN | 4 | Paradise in the first book of the Bible |
| 47% | APOCRYPHA | 9 | Books included as an appendix to the Old Testament in certain versions of the Bible |
| 47% | ASTOR | 5 | Nancy —, first woman to sit as an MP in the House of Commons |
| 47% | ONTHELINE | 9 | In jeopardy ... and where the first words of the answers to starred clues can be found |
| 47% | ELOCUTIONPHRASE | 15 | Exercise in pronunciation ... like the first words of the answers to the starred clues |
| 46% | GOT | 3 | First book in the series "A Song of Ice and Fire," familiarly |
| 46% | MARATSA{FIN} | 12 | First Russian to be inducted in the International Tennis Hall of Fame |
| 46% | CELSHADING | 10 | Technique often used to make 3D images appear in the style of a comic book |
| 46% | EPHRAIM | 7 | Second son of Joseph and Asenath according to the Book of Genesis in the Bible |
| 46% | GOD | 3 | What each set of circled letters is, relative to the first word in its answer |
| 46% | EZRA | 4 | Book that begins "Now in the first year of Cyrus king of Persia ..." |
| 46% | JET | 3 | The Lippisch Ente was the first one of these to fly, in 1928 |
| 46% | CATO | 4 | Ancient Roman senator mentioned in the first chapter of “Moby-Dick” |
| 46% | NAME | 4 | Info to fill in on the first line of many forms |
| 45% | TONI | 4 | First name of the first Black woman to win a Nobel Prize in Literature |