| 100% | CARRIEPRESTON | 13 | "The Good Wife" actress who plays the title role on the CBS spin-off of "The Good Wife," "Elsbeth" (2 wds.) |
| 62% | GINARODRIGUEZ | 13 | Actress who plays the title role on 15-Across: 2 wds. |
| 62% | KENNEDYMCMANN | 13 | Actress who plays the title role on "Nancy Drew": 2 wds. |
| 56% | LINDALAVIN | 10 | Actress who played the title character on the sitcom "Alice": 2 wds. |
| 55% | ARCHIEPANJABI | 13 | Actress who plays investigator Kalinda Sharma on "The Good Wife": 2 wds. |
| 55% | AMYPOEHLER | 10 | Actress who played the role of Leslie Knope in "Parks and Recreation", a role she is best-known for: 2 wds. |
| 55% | SUSIEESSMAN | 11 | Actress who plays the foul-mouthed wife of the main character's manager Jeff on "Curb Your Enthusiasm": 2 wds. |
| 54% | SUSANSARANDON | 13 | Actress who played Louise, one of the title characters on the run in 1991's "Thelma & Louise": 2 wds. |
| 54% | CARRIEPRESTON | 13 | "The Good Wife" actress who stars in the spin-off "Elsbeth" as a lawyer catching criminals: 2 wds. |
| 54% | ANNAFARIS | 9 | Actress who played Christy Plunkett on the first seven seasons of the CBS sitcom "Mom": 2 wds. |
| 54% | OLIVIAMUNN | 10 | "The Predator" actress who plays the title role in "Violet": 2 wds. |
| 54% | EDIEFALCO | 9 | "The Sopranos" actress who played the title character on "Nurse Jackie": 2 wds. |
| 54% | KEELEYHAWES | 11 | "The Missing" actress who plays Dr. Kira Manning in the "Echoes" spin-off of 18-Across: 2 wds. |
| 54% | BENPLATT | 8 | "The Politician" star who plays the title role in the movie adaptation of "Dear Evan Hansen": 2 wds. |
| 53% | DARCYCARDEN | 11 | "The Good Place" actress who plays Greta on the 2022 TV series "A League of Their Own" (2 wds.) |
| 53% | HELENEYORKE | 11 | "The Good Fight" actress who plays one of the siblings on 36-Across (2 wds.) |
| 53% | RAMONRODRIGUEZ | 14 | "Charlie's Angels" actor who plays the title role on 16-Across: 2 wds. |
| 53% | JULIAROBERTS | 12 | "Pretty Woman" actress who played the title role in 2000's "Erin Brockovich": 2 wds. |
| 52% | HOPEDAVIS | 9 | "Wayward Pines" actress who plays the wife of a mob boss on 54-Across (2 wds.) |
| 52% | LILYCOLLINS | 11 | Actress who plays the title character on 46-Across (2 wds.) |
| 52% | ALANRITCHSON | 12 | "Titans" actor who plays the title role on the Amazon series "Reacher" (2 wds.) |
| 51% | JULIEANDREWS | 12 | "The Princess Diaries" actress who played the title role in the 1957 TV movie musical "Cinderella" (2 wds.) |
| 51% | NATALIEDORMER | 13 | "Game of Thrones" actress who played 32-Across on the CBS series "Elementary" (2 wds.) |
| 51% | BROOKESHIELDS | 13 | "The Blue Lagoon" actress who played the title character on 46-Across (2 wds.) |
| 51% | HELENMIRREN | 11 | "The Queen" actress who plays the title role in "Golda" (2 wds.) |
| 51% | DIANEKEATON | 11 | Winner of a Best Actress Oscar for playing Annie Hall, the title role of 1977's Best Picture: 2 wds. |
| 51% | FRANKIEADAMS | 12 | Actress who plays the role of Bobbie Draper in the science fiction TV series "The Expanse": 2 wds. |
| 51% | KRYSTENRITTER | 13 | "Jessica Jones" actress who plays Lucy in the "Echoes" spin-off of 18-Across: 2 wds. |
| 51% | ELISABETHMOSS | 13 | American actress who plays the lead role of Offred in the series in 18a: 2 wds. |
| 51% | CLAIREFOY | 9 | Actress who plays Queen Elizabeth II on the first two seasons of "The Crown" (2 wds.) |