| 100% | VIOLADAVIS | 10 | "The Help" actress who plays First Lady Obama in the upcoming Showtime series "The First Lady": 2 wds. |
| 53% | PENELOPEANN | 11 | With 50-Across, "Carlito's Way" actress who plays the First Lady in 16-Across: 2 wds. |
| 50% | MERYLSTREEP | 11 | Actress who plays Mary Wright, in the Emmy-winning drama series "Big Little Lies": 2 wds. |
| 50% | EILEENBRENNAN | 13 | Actress who played Doreen Lewis in both the movie and TV series "Private Benjamin": 2 wds. |
| 50% | TAMALAJONES | 11 | "Castle" actress who plays private investigator Lana in the TV series "Rebel": 2 wds. |
| 49% | ELISABETHMOSS | 13 | American actress who plays the lead role of Offred in the series in 18a: 2 wds. |
| 47% | LAURAPREPON | 11 | Actress who played Alex Vause, an inmate in the TV series "Orange Is the New Black": 2 wds. |
| 47% | NATASHALYONNE | 13 | Actress who played Nicky Nichols, an inmate in the TV series "Orange Is the New Black": 2 wds. |
| 47% | ANNETTEBENING | 13 | "American Beauty" actress who plays Euphemia in the upcoming movie "Death on the Nile": 2 wds. |
| 47% | JULIAROBERTS | 12 | Actress who plays Heidi Bergman in the psychological thriller web TV series, "Homecoming": 2 wds. |
| 47% | CLAIREFOY | 9 | Actress who played Queen Elizabeth II in the historical drama TV series "The Crown" and also starred in "Crossbones" as Kate Balfour: 2 wds. |
| 47% | URSULAANDRESS | 13 | Swiss actress who played the first Bond girl in "Dr. No": 2 wds. |
| 47% | FRANKIEADAMS | 12 | Actress who plays the role of Bobbie Draper in the science fiction TV series "The Expanse": 2 wds. |
| 46% | KATEMULGREW | 11 | Actress who played Galina "Red" Reznikov, an inmate in the TV series "Orange Is the New Black": 2 wds. |
| 46% | DEBRAMESSING | 12 | Actress who played 17a in the series for which she won a Primetime Emmy Award: 2 wds. |
| 46% | KATIEHOLMES | 11 | "Dawson's Creek" actress who plays former First Lady Jackie Kennedy in "The Kennedys" (2 wds.) |
| 46% | ZOESALDANA | 10 | "Avatar" actress who played a pirate in the first "Pirates of the Caribbean" film: 2 wds. |
| 46% | VANESSAKIRBY | 12 | Actress who played Princess Margaret in the historical drama TV series "The Crown" and also starred in "Hobbs and Shaw" as Hattie Shaw: 2 wds. |
| 46% | VANESSAKIRBY | 12 | "The Crown" actress who plays Invisible Woman in "The Fantastic Four: First Steps": 2 wds. |
| 46% | LILYJAMES | 9 | Actress who plays an English archaeologist in the 2021 film "The Dig": 2 wds. |
| 46% | OCTAVIASPENCER | 14 | "Ma" actress who plays hair care mogul Madam C.J. Walker in the Netflix series "Self Made": 2 wds. |
| 46% | EVELYNKEYES | 11 | Actress who played Suellen O'Hara in the film "Gone With the Wind": 2 wds. |
| 45% | FELICITYJONES | 13 | Actress who played Ruth Bader Ginsburg in the film "On the Basis of Sex": 2 wds. |
| 45% | LUCYLIU | 7 | Actress who plays 22-Across/41-Across in the CBS series "Elementary" (2 wds.) |
| 45% | URSULAANDRESS | 13 | Swiss actress who played Bond girl Honey Ryder in the first ever James Bond film "Dr. No.": 2 wds. |
| 45% | SHERILYNFENN | 12 | Actress who is known for playing Audrey Horne in the cult TV series "Twin Peaks": 2 wds. |
| 45% | MAURATIERNEY | 12 | "The Affair" actress who plays Grace Poe in the Showtime adaptation of 46-Across (2 wds.) |
| 45% | DIANEKRUGER | 11 | Actress who plays Dr. Abigail Chase in the "National Treasure" films: 2 wds. |
| 45% | CATEBLANCHETT | 13 | Actress who played Queen Elizabeth I in the 1998 movie "Elizabeth": 2 wds. |
| 45% | MARGOTROBBIE | 12 | Actress who has voiced Harley Quinn in the upcoming animated film "The Lego Movie 2: The Second Part": 2 wds. |