| 100% | MARTINFREEMAN | 13 | "The Hobbit" actor who plays Dr. Watson on the BBC's "Sherlock": 2 wds. |
| 70% | MARTINFREEMAN | 13 | Actor from "The Hobbit", who plays Doctor John Watson in BBC's "Sherlock": 2 wds. |
| 68% | JUDELAW | 7 | "Alfie" actor who played Dr. Watson in the movie "Sherlock Holmes": 2 wds. |
| 61% | WILLFERRELL | 11 | "Anchorman" actor who plays Sherlock Holmes in the upcoming movie "Holmes & Watson": 2 wds. |
| 60% | MARTINFREEMAN | 13 | Actor who plays 22-Across/41-Across on the BBC series "Sherlock" (2 wds.) |
| 59% | TIMROTH | 7 | "Pulp Fiction" actor who played Dr. Cal Lightman on the Fox series "Lie To Me": 2 wds. |
| 58% | JOHNMALKOVICH | 13 | "The New Pope" actor who plays Dr. Adrian Mallory on "Space Force": 2 wds. |
| 58% | ROBERTSEAN | 10 | With 25-Across, actor who played Dr. James Wilson (based on 47-Across) on the Fox series "House": 2 wds. |
| 57% | JUDELAW | 7 | Actor who plays John Watson in the 2009 film "Sherlock Holmes" (2 wds.) |
| 57% | BOYDHOLBROOK | 12 | "Logan" actor who plays the Corinthian on "The Sandman": 2 wds. |
| 56% | MARTINFREEMAN | 13 | Actor who portrays Dr. John Watson in the British crime drama "Sherlock": 2 wds. |
| 56% | OMIDABTAHI | 10 | "American Gods" actor who plays Dr. Pershing on "The Mandalorian" (2 wds.) |
| 56% | JOSHCHARLES | 11 | "The Good Wife" actor who plays the astronaut's husband on "Away": 2 wds. |
| 56% | JASONLEE | 8 | "My Name Is Earl" actor who plays the president's brother on "The Residence": 2 wds. |
| 55% | RAMONRODRIGUEZ | 14 | "Charlie's Angels" actor who plays the title role on 16-Across: 2 wds. |
| 55% | KELSEYGRAMMER | 13 | Actor who played Dr. Frasier Crane on "Frasier": 2 wds. |
| 55% | ALEXKARRAS | 10 | Actor who played the adoptive father on "Webster": 2 wds. |
| 55% | EMMANUELLEWIS | 13 | Actor who played the title character on "Webster": 2 wds. |
| 55% | JOSHUAJACKSON | 13 | Actor who played Pacey on the 1998-2003 teen drama "Dawson's Creek": 2 wds. |
| 55% | LARAPULVER | 10 | "Spooks" actress who played 32-Across on the BBC series "Sherlock" (2 wds.) |
| 55% | CLANCYBROWN | 11 | "The Shawshank Redemption" actor who plays Rich Brink on Amazon's "Gen V": 2 wds. |
| 55% | IANMCSHANE | 10 | The actor who plays Mr. Wednesday on the TV series "American Gods": 2 wds. |
| 54% | RYANEGGOLD | 10 | "The Blacklist" actor who plays Dr. Max Goodwin on "New Amsterdam" (2 wds.) |
| 54% | SEANGIAMBRONE | 13 | Actor who plays the geeky boy, Adam, on 18-Across: 2 wds. |
| 54% | VICTAYBACK | 10 | Actor who played diner owner Mel on the sitcom "Alice": 2 wds. |
| 54% | DANIELKALUUYA | 13 | Actor who plays Slim, one of the title characters on the run in 2019's "Queen & Slim": 2 wds. |
| 54% | RONLEIBMAN | 10 | "Norma Rae" actor who played Rachel's father, Dr. Leonard Green, on "Friends": 2 wds. |
| 54% | GEOFFREYRUSH | 12 | "Shine" actor who played Albert Einstein on the 2017 Nat Geo series "Genius": 2 wds. |
| 54% | HARRYMORGAN | 11 | Actor who played Colonel Sherman T. Potter on the 1972-1983 sitcom "M*A*S*H": 2 wds. |
| 54% | COLINFARRELL | 12 | "Horrible Bosses" actor who plays Ray Velcoro on the latest season of "True Detective": 2 wds. |