| 100% | HENRIETTA | 9 | "The Immortal Life of ___ Lacks" (non-fiction best-seller by Rebecca Skloot) |
| 46% | HENRIETTA | 9 | "The Immortal Life of ___ Lacks" |
| 40% | OPRAH | 5 | Former TV host who stars in HBO's "The Immortal Life of Henrietta Lacks" |
| 40% | THESEAAROUNDUS | 14 | Best-selling book by 19-Across about the life history of our oceans: 4 wds. |
| 39% | WORLDS | 6 | "The War of the ___," 1897 science fiction novel by H.G. Wells about alien invasion |
| 38% | OPRAH | 5 | Actress Winfrey of "The Immortal Life of Henrietta Lacks" |
| 37% | OUTLIERS | 8 | "___: The Story of Success," non-fiction book by Malcolm Gladwell |
| 36% | OPRAH | 5 | Star of HBO's "The Immortal Life of Henrietta Lacks" |
| 36% | OPRAH | 5 | Winfrey of HBO's "The Immortal Life of Henrietta Lacks" |
| 36% | WHATHAPPENED | 12 | 2017 best seller by Hillary Clinton about the 2016 election: 2 wds. |
| 36% | CLAN | 4 | "The ___ of the Cave Bear" (1980 best seller by Jean Auel) |
| 35% | RAINMAN | 7 | Best Picture Oscar winner inspired by the life of Kim Peek |
| 35% | KONTIKI | 7 | 1950 best seller subtitled "Across the Pacific by Raft" |
| 35% | TARTS | 5 | Goods stolen by the Knave of Hearts |
| 35% | OPRAH | 5 | Actress Winfrey of HBO's "The Immortal Life of Henrietta Lacks" |
| 34% | HANNIBAL | 8 | One of the best-selling gothic novels of the 90s written by Thomas Harris that revolves around Lecter's life as a serial killer |
| 34% | IDEOLOGY | 8 | The set of beliefs that a culture lives by |
| 34% | DAYS | 4 | "... those were the best ___ of my life..." |
| 34% | EMT | 3 | Occupation symbolized by the Star of Life |
| 33% | WORLDS | 6 | The War of the __, novel by UK writer HG Wells |
| 33% | DANIELLE | 8 | __ Steel, best-selling fiction author of The Gift |
| 33% | HAS | 3 | "This ___ been the best day of my life!" |
| 33% | PORTRAITS | 9 | With 45-Across, 2017 best seller by George W. Bush featuring his paintings of modern military heroes |
| 33% | LAP | 3 | In the ___ of luxury (living the good life) |
| 33% | INSOMNIA | 8 | Sleeping disorder identified by the lack of sleep |
| 33% | CATCHERINTHERYE | 15 | Best seller of 1951, with "The" |
| 33% | BIOGRAPHY | 9 | The story of one person's life as told by another |
| 33% | ROOTS | 5 | 1976 best seller that opens "four days upriver from the coast of The Gambia" |
| 33% | MONEYBALL | 9 | Michael Lewis best seller with the subtitle "The Art of Winning an Unfair Game" |