| 100% | EBAY | 4 | "The meaning of life" once sold on it for $3.26 |
| 69% | EBAY | 4 | Where the meaning of life was sold in 2000 for $3.26 |
| 46% | FISHERMAN | 9 | "The ___ and the Little Fish," a popular fable by 38-Down about a small fish that begs for its life on account of its size |
| 46% | MADEINAMERICA | 13 | "O.J.:___," documentary series, based on the life of O. J. Simpson, that won the Oscar for Best Documentary Feature in 2016: 3 wds. |
| 45% | ONAWHIM | 7 | For the heck of it: 3 wds. |
| 44% | AIDA | 4 | Its Act 3 is set on the banks of the Nile |
| 44% | PHILOSOPHICALLY | 15 | Relating to the meaning of life |
| 42% | ALEXA | 5 | "___, what is the meaning of life?" (modern query) |
| 42% | BELIEFS | 7 | Convictions a person has about the meaning of life |
| 41% | SIRI | 4 | iPhone assistant who says that "42" is the meaning of life |
| 41% | RHINOCEROS | 10 | The White ___, one of the largest terrestrial animals on the planet that is known for its large horn |
| 41% | GLORY | 5 | "Bound for ___," 1976 musical starring David Carradine that is based on the life of Woody Guthrie |
| 40% | JOHN | 4 | Elton who performed "The Circle of Life" with the Broadway cast of "The Lion King" on its 20th anniversary |
| 40% | SEIZE | 5 | “___ the means of production” (text on many Marx-inspired memes) |
| 40% | LARK | 4 | On a ___ (just for the fun of it) |
| 38% | TAPWATER | 8 | Meaning of "one on the city," in diner lingo |
| 38% | ETNA | 4 | About a quarter of the population of Sicily lives on its slopes |
| 38% | OLLIE | 5 | "Stan & ___," 2018 comedy movie based on the lives of Laurel and Hardy |
| 38% | ROOT | 4 | The Gaelic "uisge beatha," meaning "water of life," for "whiskey" |
| 38% | SOUNDSLIKEAPLAN | 15 | "Let's do it!" ... or comment on the last words of 16-, 26- and 47-Across, when said together out loud |
| 38% | WORLD | 5 | The population of earth and everything on it |
| 38% | NON | 3 | This prefix when used, changes the meaning of the word to its opposite |
| 37% | RED | 3 | It represents life on the rainbow flag |
| 37% | GOP | 3 | It's on the right, for short |
| 37% | YALE | 4 | It's #3 on the U.S. News and World Report list of top American universities |
| 37% | ONAWHIM | 7 | For the heck of it |
| 37% | VARIETY | 7 | It is the spice of life, proverbially speaking |
| 37% | SQUAREPEG | 9 | It's not meant for a 3-Down |
| 37% | ASPHALT | 7 | It might be on the road for years |
| 37% | ASIA | 4 | It's on one side of the Urals |