| 100% | JOHNMALKOVICH | 13 | "The New Pope" actor who plays Dr. Adrian Mallory on "Space Force": 2 wds. |
| 67% | JOHNMALKOVICH | 13 | "The New Pope" actor who plays a scientist on "Space Force" (2 wds.) |
| 58% | STEVECARELL | 11 | "The Office" actor who plays Gen. Mark Naird on "Space Force": 2 wds. |
| 55% | MARTINFREEMAN | 13 | "The Hobbit" actor who plays Dr. Watson on the BBC's "Sherlock": 2 wds. |
| 55% | STEVECARELL | 11 | "The Office" actor who plays the first Chief of Space Operations on "Space Force" (2 wds.) |
| 55% | ROBERTSEAN | 10 | With 25-Across, actor who played Dr. James Wilson (based on 47-Across) on the Fox series "House": 2 wds. |
| 55% | TIMROTH | 7 | "Pulp Fiction" actor who played Dr. Cal Lightman on the Fox series "Lie To Me": 2 wds. |
| 53% | RYANEGGOLD | 10 | "The Blacklist" actor who plays Dr. Max Goodwin on "New Amsterdam" (2 wds.) |
| 52% | KELSEYGRAMMER | 13 | Actor who played Dr. Frasier Crane on "Frasier": 2 wds. |
| 51% | NICKSANDOW | 10 | Former "Third Watch" actor who plays Joe Caputo on "Orange Is the New Black" (2 wds.) |
| 51% | OLIVERPLATT | 11 | "Huff" actor who plays Dr. Daniel Charles on "Chicago Med": 2 wds. |
| 51% | MARKHARMON | 10 | "NCIS" actor who played Dr. Robert Caldwell on "St. Elsewhere": 2 wds. |
| 51% | ALEXKARRAS | 10 | Actor who played the adoptive father on "Webster": 2 wds. |
| 51% | EMMANUELLEWIS | 13 | Actor who played the title character on "Webster": 2 wds. |
| 51% | JUDELAW | 7 | "Alfie" actor who played Dr. Watson in the movie "Sherlock Holmes": 2 wds. |
| 50% | NATHANFILLION | 13 | "Castle" actor who plays new cop John Nolan on the new ABC police drama "The Rookie" (2 wds.) |
| 50% | EZRAMILLER | 10 | Actor who plays the title character in the new movie "The Flash": 2 wds. |
| 50% | SPENCERTRACY | 12 | Actor who played the lawyer based on Clarence Darrow in 32-Across: 2 wds. |
| 50% | SEANGIAMBRONE | 13 | Actor who plays the geeky boy, Adam, on 18-Across: 2 wds. |
| 50% | LAMORNEMORRIS | 13 | "New Girl" actor who plays cartoonist Keef Knight, newly attuned to racial injustice, on the Hulu comedy "Woke": 2 wds. |
| 50% | JAREDLETO | 9 | "Suicide Squad" actor who plays Dr. Michael Morbius in the upcoming movie "Morbius": 2 wds. |
| 50% | RANDALLPARK | 11 | Actor who plays Louis, the dad on "Fresh Off the Boat": 2 wds. |
| 50% | DANNYBONADUCE | 13 | Actor who played the wisecracking middle child on "The Partridge Family": 2 wds. |
| 50% | BOYDHOLBROOK | 12 | "Logan" actor who plays the Corinthian on "The Sandman": 2 wds. |
| 49% | KELSEYGRAMMER | 13 | Actor who played Dr. Frasier Crane in "Frasier" and "Cheers", and hosted the 1998 Grammy Awards: 2 wds. |
| 49% | KIERANCULKIN | 12 | "Succession" actor who plays Benji in the new movie "A Real Pain": 2 wds. |
| 49% | JOSHCHARLES | 11 | "The Good Wife" actor who plays the astronaut's husband on "Away": 2 wds. |
| 49% | RAMONRODRIGUEZ | 14 | "Charlie's Angels" actor who plays the title role on 16-Across: 2 wds. |
| 49% | OMIDABTAHI | 10 | "American Gods" actor who plays Dr. Pershing on "The Mandalorian" (2 wds.) |
| 49% | CHRISELLIOTT | 12 | "Groundhog Day" actor who plays the mayor on 19-Across: 2 wds. |