| 100% | DRWHOSYOURDADDY | 15 | "The paternity results are in ... it's the protagonist of a long-running BBC sci-fi show!"? |
| 40% | ASL | 3 | It's sometimes shown in the corner of a TV screen, for short |
| 40% | THEXFILES | 9 | American sci-fi TV show starring David Duchovny, that is regarded as one of the best and is returning with its 11th season in 2018: 2 wds. |
| 39% | CRIMESCENE | 10 | "CSI: ___," with 31-Across, the name of a TV show Liev Schreiber - whose birthday it is today - guest starred in as Michael Keppler: 2 wds. |
| 39% | GOT | 3 | "America's ___ Talent," a long running talent show featuring the likes of Nick Cannon and Sharon Osbourne |
| 38% | ATM | 3 | It might be found in the corner of a corner store |
| 38% | TRAGEDY | 7 | In theater, it's the opposite of a comedy |
| 38% | IRIS | 4 | A pupil is in the middle of it |
| 38% | IRIS | 4 | A pupil is in the center of it |
| 38% | FROSTBITE | 9 | Hazard of being outside in the cold for a long time |
| 38% | EROSION | 7 | Long-term result of a run on the bank? |
| 38% | BIO | 3 | It might be in the form of a thumbnail |
| 38% | TREK | 4 | "Star ___," sci-fi show that is a favorite of the characters on "The Big Bang Theory" |
| 37% | OPERA | 5 | Word in the title of Broadway's longest-running show |
| 37% | THINGS | 6 | "Stranger ___," sci-fi show starring Millie Bobby Brown that follows a group of friends in the '80s |
| 37% | AREA | 4 | "___ 51," 2015 sci-fi horror film with the number of a famous, highly classified Air Force facility in its title |
| 37% | TEENMOM | 7 | Reality show that documented the lives of four young mothers, and was a spin-off of "16 and Pregnant" and is in its 7th season: 2 wds. |
| 37% | MINUET | 6 | It's done in the form of an S or a Z |
| 37% | DIE | 3 | What a laptop battery will do in the long run? |
| 37% | DAVID | 5 | & 19D Presenter of BBC TV shows It's a Knockout and A Question of Sport who died in 2009 |
| 36% | LATETAG | 7 | It results in a runner being called safe |
| 36% | COD | 3 | The oil in its liver is a source of omega-3 fatty acids |
| 36% | THEDOCTOR | 9 | Time Lord whose 11th incarnation was played by 15-Across on a long-running BBC sci-fi series: 2 wds. |
| 36% | STEER | 5 | Be in control of the wheel of a car |
| 36% | TAN | 3 | Farmer's ___ (result of wearing a short-sleeved shirt in the sun for a long time) |
| 36% | IGNITION | 8 | Part of a vehicle the key is pushed in to start it |
| 36% | ASHRAM | 6 | In the Mahabharata, it's stated that a youthful Krishna was sent to see Sand?pan? Muni at one of these |
| 36% | BILL | 4 | ___ Nye, host of the eponymous science show who was a household icon in '90s children's TV |
| 36% | TAN | 3 | Color of skin that has been in the sun for a long time |