| 100% | HELENMIRREN | 11 | "The Queen" actress who plays the title role in "Golda" (2 wds.) |
| 88% | OLIVIAMUNN | 10 | "The Predator" actress who plays the title role in "Violet": 2 wds. |
| 83% | JULIAROBERTS | 12 | "Pretty Woman" actress who played the title role in 2000's "Erin Brockovich": 2 wds. |
| 79% | GINARODRIGUEZ | 13 | Former "The Bold and the Beautiful" actress who plays the title role in 41-Across (2 wds.) |
| 78% | IRENEBEDARD | 11 | Actress who voiced the title role in "Pocahontas": 2 wds. |
| 78% | JULIEANDREWS | 12 | "The Princess Diaries" actress who played the title role in the 1957 TV movie musical "Cinderella" (2 wds.) |
| 77% | CAMILACABELLO | 13 | "Trolls Band Together" voice actress who played the title role in the 2021 movie musical "Cinderella" (2 wds.) |
| 77% | JASONMOMOA | 10 | "Conan the Barbarian" star who plays the title role in "Aquaman": 2 wds. |
| 76% | MARGOTROBBIE | 12 | "Babylon" actress who plays the title character in "Barbie": 2 wds. |
| 76% | ELLIEKEMPER | 11 | Actress who plays the lead role in 12-/24-Across: 2 wds. |
| 75% | GINARODRIGUEZ | 13 | Actress who plays the title role on 15-Across: 2 wds. |
| 75% | KENNEDYMCMANN | 13 | Actress who plays the title role on "Nancy Drew": 2 wds. |
| 74% | MATTHEWRHYS | 11 | "The Americans" actor who plays the title role in HBO's "Perry Mason": 2 wds. |
| 74% | JULIEANDREWS | 12 | Actress who won an Oscar for playing the title role in 39-Across: 2 wds. |
| 74% | DENNISQUAID | 11 | "Flight of the Phoenix" actor who plays the title role in 16-Across: 2 wds. |
| 73% | TONYTODD | 8 | "Final Destination" actor who plays the title role in 16-Across: 2 wds. |
| 73% | HENRYFONDA | 10 | "On Golden Pond" actor who played the title role in 32-Across: 2 wds. |
| 73% | BENPLATT | 8 | "The Politician" star who plays the title role in the movie adaptation of "Dear Evan Hansen": 2 wds. |
| 72% | SARAHPAULSON | 12 | "American Horror Story" actress who plays the title character in Netflix's "Ratched": 2 wds. |
| 72% | EWANMCGREGOR | 12 | "Beauty and the Beast" actor who plays the title role in the new movie "Christopher Robin": 2 wds. |
| 72% | MIKEMYERS | 9 | "SNL" alum who played the title roles in the "Austin Powers" and "Shrek" movies: 2 wds. |
| 72% | EDDIEMURPHY | 11 | "Coming to America" actor who played the title role in 1998's "Dr. Dolittle": 2 wds. |
| 71% | JAREDLETO | 9 | "Blade Runner 2049" actor who plays the title role in "Morbius" (2 wds.) |
| 71% | LIAMNEESON | 10 | "Schindler's List" actor who plays the title role in "Marlowe" (2 wds.) |
| 70% | ANGELABASSETT | 13 | Actress who plays the queen mother of Wakanda in "Black Panther": 2 wds. |
| 70% | CATEBLANCHETT | 13 | Actress who played Queen Elizabeth I in the 1998 movie "Elizabeth": 2 wds. |
| 70% | ELISABETHMOSS | 13 | American actress who plays the lead role of Offred in the series in 18a: 2 wds. |
| 70% | AUSTINBUTLER | 12 | "Once Upon a Time in Hollywood" actor who plays the title role in "Elvis" (2 wds.) |
| 70% | RACHELMCADAMS | 13 | "Doctor Strange" actress who plays the title character's mom in 33-/49-Across: 2 wds. |