| 100% | SLIMSHADY | 9 | "The Real ___," Eminem's first song to reach number one in the U.K, with a video that parodied several real-life celebrities: 2 wds. |
| 37% | WITHOUTME | 9 | A song by rapper Eminem - whose birthday it is today - which featured a video that parodied comics in general: 2 wds. |
| 37% | BADROMANCE | 10 | 2009 song by Lady Gaga that made her the first female in British chart history to have three number-one singles in one year: 2 wds. |
| 33% | BADGUY | 6 | 2019 song by Billie Eilish which reached number one in the Billboard Hot 100 replacing 27a: 2 wds. |
| 33% | IKEA | 4 | Company that was the first in the U.S. to air a TV ad with a gay couple (1994) |
| 32% | GANGNAMSTYLE | 12 | 2012 song by Psy that made him the first Korean singer to top the U.K. singles chart: 2 wds. |
| 32% | PROUDMARY | 9 | Girl in a Tina Turner song from the soundtrack of "What's Love Got to Do with It": 2 wds. |
| 32% | MOUSELEMUR | 10 | A species unique to Madagascar that is the world's smallest primate and one of the smallest mammals in the world: 2 wds. |
| 32% | THELASTOF | 9 | "___ Us," one of the best-selling PlayStation video games released in 2013 that is set in a post-apocalyptic U.S.: 3 wds. |
| 31% | PINBALLWIZARD | 13 | "Tommy" song sung by 47-Across that's the only cover of a Who song to reach the Top 10 (2 wds.) |
| 31% | JOHNMELLENCAMP | 14 | "Jack & Diane" singer who had a hit in 1986 with "R.O.C.K. in the U.S.A.": 2 wds. |
| 31% | MOTORSPEEDWAY | 13 | Indianapolis ___, the race track to have claimed the most number of lives in Formula One : 2 wds. |
| 31% | ONEMISSISSIPPI | 14 | 2021 Kane Brown song with a state in its name that hit the top 40: 2 wds. |
| 30% | ROALDAMUNDSEN | 13 | Norwegian explorer who in 1911 became the first person to reach the South Pole, one month ahead of 18-Across: 2 wds. |
| 30% | RODSTEWART | 10 | Singer who performed his song "Infatuation" to open the first MTV Video Music Awards, in 1984: 2 wds. |
| 30% | KATYPERRY | 9 | "Roar" singer with more than 42 million YouTube subscribers who was the first artist to have multiple music videos reach one billion views on YouTube (2 wds.) |
| 30% | DONKEYKONG | 10 | Video game with a gorilla that first featured the main character of 43-Across (2 wds.) |
| 30% | LOUISVUITTON | 12 | Fashion house that collaborated with the Final Fantasy XIII video game franchise in 2016 to create a new look for the heroine Lightning (2 wds.) |
| 30% | FUNNYBONE | 9 | Spot in the elbow with a nerve that's "shocking" when struck: 2 wds. |
| 30% | RAPGOD | 6 | Eminem song which holds the world record for most words in a hit single with an average of 4.28 words per second: 2 wds. |
| 29% | TOMMYGUNN | 9 | Rocky's opponent in "Rocky V," played by real-life boxer Morrison (who shares a first name with his character): 2 wds. |
| 29% | LUCY | 4 | One in the sky with diamonds, according to a Beatles song |
| 29% | GREENBOOK | 9 | 2018 drama starring Mahershala Ali that's one of six PG-13 films to win a Best Picture Oscar in the 21st century (2 wds.) |
| 29% | BEOUR | 5 | With 35-Across, Oscar-nominated song from Disney's "Beauty and the Beast" that lost to that movie's title song: 2 wds. |
| 29% | BOOMBAYAH | 9 | 2020 51-Across song that was the first K-pop debut music video to pass one billion views on YouTube |
| 29% | IGET | 4 | "___ Around," the first number-one charting song released by The Beach Boys in 1964: 2 wds. |
| 29% | ISLANDSIN | 9 | With 40-Across, song that reached #1 on Billboard's country and Hot 100 charts in 1983: 2 wds. |
| 29% | TIGERWOODS | 10 | Golfer who won the 2008 U.S. Open with a double fracture in his tibia: 2 wds. |
| 29% | OZONELAYER | 10 | Shielding region in the stratosphere, that has a hole thanks to human activities: 2 wds. |
| 29% | SWEETCHILD | 10 | 19a's hit song "___ o' Mine" which is the band's only song to hit number one on the Billboard Hot 100: 2 wds. |