| 100% | SARAGILBERT | 11 | "The Talk" cohost who plays Roseanne's daughter Darlene on "Roseanne": 2 wds. |
| 60% | TALITHABATEMAN | 14 | "Annabelle: Creation" actress who plays the astronaut's daughter on "Away": 2 wds. |
| 57% | LAURIEMETCALF | 13 | "Lady Bird" costar who plays Roseanne's sister Jackie on "Roseanne": 2 wds. |
| 55% | JOHNGOODMAN | 11 | "Kong: Skull Island" star who plays Roseanne's husband Dan on "Roseanne": 2 wds. |
| 53% | ROWANBLANCHARD | 14 | Actress who plays Topanga's daughter Riley on 33-Across: 2 wds. |
| 53% | SALLYSTRUTHERS | 14 | Actress who played Archie's daughter Gloria on 16-Across: 2 wds. |
| 52% | JOSHCHARLES | 11 | "The Good Wife" actor who plays the astronaut's husband on "Away": 2 wds. |
| 51% | ALEXISBLEDEL | 12 | "The Sisterhood of the Traveling Pants" actress who played daughter Rory on 14-Across: 2 wds. |
| 51% | LILIREINHART | 12 | Actress who plays Betty on the CW's "Riverdale": 2 wds. |
| 51% | HARRISONFORD | 12 | "Indiana Jones and the Dial of Destiny" actor who plays Jimmy's mentor Paul on "Shrinking": 2 wds. |
| 51% | SETHROGEN | 9 | "The Studio" actor who plays Sylvia's friend Will on "Platonic": 2 wds. |
| 50% | COBIESMULDERS | 13 | "Stumptown" actress who plays former S.H.I.E.L.D. agent Maria Hill on the Disney+ series "Secret Invasion": 2 wds. |
| 50% | AMANDASEYFRIED | 14 | "Ted 2" actress who plays Donna's daughter Sophie in the "Mamma Mia!" sequel: 2 wds. |
| 50% | RAMONRODRIGUEZ | 14 | "Charlie's Angels" actor who plays the title role on 16-Across: 2 wds. |
| 49% | MARTINFREEMAN | 13 | "The Hobbit" actor who plays Dr. Watson on the BBC's "Sherlock": 2 wds. |
| 49% | ODETTEANNABLE | 13 | "Supergirl" actress who plays Geri Broussard on The CW's "Walker": 2 wds. |
| 49% | COURTENEYCOX | 12 | Actress who played the chef Monica Geller on "Friends": 2 wds. |
| 49% | JASONLEE | 8 | "My Name Is Earl" actor who plays the president's brother on "The Residence": 2 wds. |
| 48% | GILDARADNER | 11 | Roseanne Roseannadanna portrayer on "SNL" who wrote the memoir "It's Always Something": 2 wds. |
| 48% | ALLISONJANNEY | 13 | Actress who plays Bonnie, the title mom on "Mom": 2 wds. |
| 48% | LAURAPREPON | 11 | "The Girl on the Train" actress, who played Donna Pinciotti in "That 70's Show": 2 wds. |
| 48% | DIANEGUERRERO | 13 | "Jane the Virgin" actress who plays Crazy Jane on DC Universe's "Doom Patrol": 2 wds. |
| 48% | JEANNIEMAI | 10 | "The Real" cohost who is the sideline correspondent on 17-Across: 2 wds. |
| 48% | EDIEFALCO | 9 | "The Sopranos" actress who played the title character on "Nurse Jackie": 2 wds. |
| 48% | LUKEKLEINTANK | 13 | "The Man in the High Castle" actor who plays team leader Scott Forrester on CBS's "FBI: International": 2 wds. |
| 47% | SCOTTWOLF | 9 | "Party of Five" star who plays Nancy's dad on the CW's "Nancy Drew": 2 wds. |
| 47% | ALFONSORIBEIRO | 14 | "Dancing With the Stars" host who played one of Ricky's friends on 19-Across: 2 wds. |
| 47% | CHERYLHINES | 11 | Actress who plays the main character's ex-wife on "Curb Your Enthusiasm": 2 wds. |
| 47% | JOSHUAJACKSON | 13 | Actor who played Pacey on the 1998-2003 teen drama "Dawson's Creek": 2 wds. |
| 47% | EMILYMITCHELL | 13 | "Women Talking" actress who plays Elivs Presley's daughter in "Priscilla" (2 wds.) |