| 100% | OUR | 3 | "This is ___ big chance!" |
| 100% | GOFORIT | 7 | "Act now! This is your big chance!" (3 wds.) |
| 78% | ALES | 4 | These are often drawn with big heads |
| 77% | DONTBLOWIT | 10 | Snarky comment after "This is your big chance" |
| 77% | AFRICA | 6 | This is the second biggest continent, after Asia |
| 77% | OUNCE | 5 | A jigger is bigger than this |
| 74% | HOLDONTOYOURHAT | 15 | “Get ready, because this is some big news” |
| 72% | ACCIDENTS | 9 | These happen, mishaps are no big deal |
| 71% | HUE | 3 | This and 32-Down are a big fuss |
| 70% | ELEVENTH | 8 | This hour is your last chance to do something |
| 70% | CHEETAH | 7 | This spotty big cat is the fastest land animal |
| 69% | OUR | 3 | "This is ___ last chance!" |
| 69% | LAST | 4 | "This is your ___ chance!" |
| 68% | TENT | 4 | A big flap may be made about this |
| 68% | CANYONS | 7 | Biggest of these are Grand and Fish River |
| 67% | OUR | 3 | "This is __ chance" |
| 67% | SPACEPROBE | 10 | "Why is this keyboard key bigger than the others?" |
| 67% | NAM | 3 | "Smokey, this is not ___. This is bowling. There are rules" ("The Big Lebowski" quote) |
| 65% | DONTBLOWIT | 10 | "This is your only chance" |
| 65% | NOWORNEVER | 10 | ''This is your last chance'' |
| 63% | ODOM | 4 | Former NBA star Lamar who was on "Celebrity Big Brother" this year |
| 62% | ITSNOWORNEVER | 13 | "This is our one chance to act!" |
| 62% | IHATETOASK | 10 | "This is kind of a big favor ... " |
| 62% | LAST | 4 | "This is the ___ straw!" ("No more chances!") |
| 62% | COULD | 5 | "This ___ be the start of something big..." |
| 62% | COULD | 5 | "This ___ be the start of something big" |
| 62% | RISKEDIT | 8 | Took a big chance |
| 62% | DARES | 5 | Takes a big chance |
| 62% | DARE | 4 | Take a big chance |
| 61% | COLINKAEPERNICK | 15 | He said, “To me, this is bigger than football and it would be selfish on my part to look the other way” |