| 100% | OUR | 3 | "Time of ___ Lives" (song by Pitbull and Ne-Yo) |
| 81% | OUR | 3 | "Time of ___ Lives" (2014 Pitbull and Ne-Yo song) |
| 79% | OUR | 3 | Pitbull and Ne-Yo's "Time of ___ Lives" |
| 73% | OUR | 3 | "Time of ___ Lives" (Pitbull and Ne-Yo song) |
| 54% | PARTY | 5 | "___ in the U.S.A," hit song by Miley Cyrus from her album "The Time of Our Lives" |
| 53% | LALA | 4 | 2021 song by Alicia Keys and Swae Lee performed live for the first time at the MTV Video Music Awards |
| 53% | LIFE | 4 | "___ Is a Highway," song by Tom Cochrane about driving on a road trip of life full of ups and downs |
| 51% | RESPECT | 7 | Honor ... and #5 on a list by 40-/46-Across of the 500 greatest songs of all time |
| 50% | BECRUEL | 7 | "Don't ___," a song by Elvis Presley considered one of the greatest songs of all time, reportedly covered live by The Beatles: 2 wds. |
| 49% | MIDDLEAGE | 9 | Time of life … and a hint to 17-, 28- and 45-Across |
| 49% | SOS | 3 | Title of hit songs by ABBA and Rihanna |
| 49% | SOS | 3 | Title of hit songs by Rihanna and ABBA |
| 48% | BLUEJEANS | 9 | Song by Lana Del Rey and a classic of the closet |
| 48% | IMA | 3 | "___ Freak," song by Enrique Iglesias and Pitbull: 2 wds. |
| 48% | NECROSIS | 8 | Death of living cells and tissues by many causes |
| 47% | IVE | 3 | "(___ Had) The Time of My Life" ("Dirty Dancing" theme song) |
| 47% | ILIKEIT | 7 | A 2010 hit song by Enrique Iglesias and Pitbull: 3 wds |
| 47% | PETESAMPRAS | 11 | He said "You kind of live and die by the serve" |
| 46% | EPS | 3 | The Time of Our Lives and She Is Coming, for Miley Cyrus |
| 46% | SUGAR | 5 | "___ Mountain," 1969 song by Neil Young from one of his live albums |
| 46% | DISCODUCK | 9 | 1976 #1 novelty song by Rick Dees and His Cast of Idiots |
| 46% | BOYS | 4 | Retro funk and pop song by Lizzo which was included in Time's Top Ten Best Songs of 2018 |
| 46% | REHAB | 5 | Title of songs by Rihanna and Amy Winehouse |
| 46% | SHOULDISTAY | 11 | Song by the Clash on Rolling Stone's "500 Greatest Songs of All Time" list |
| 46% | ITSOK | 5 | "___", song by Tom Rosenthal, featured in the trailers of "Comet" and "Anesthesia" : 2 wds. |
| 45% | SIGNS | 5 | "___ of Life," instrumental song by Pink Floyd from the album "A Momentary Lapse of Reason" |
| 45% | MUSIC | 5 | "The Storyteller: Tales of Life and ___" (memoir by Foo Fighters lead singer Dave Grohl) |
| 45% | TEENS | 5 | Time of life |
| 45% | OLDAGE | 6 | Time of life |
| 45% | AGE | 3 | Time of life |