| 100% | ALANRITCHSON | 12 | "Titans" actor who plays the title role on the Amazon series "Reacher" (2 wds.) |
| 72% | RAMONRODRIGUEZ | 14 | "Charlie's Angels" actor who plays the title role on 16-Across: 2 wds. |
| 69% | SHEAWHIGHAM | 11 | "Boardwalk Empire" actor who plays bureaucrat Thomas Carrasco on the Amazon series "Homecoming" (2 wds.) |
| 69% | PATRICKSTEWART | 14 | "X-Men" actor who plays the title role on 50-Across (2 wds.) |
| 69% | MATTHEWRHYS | 11 | "The Americans" actor who plays the title role on "Perry Mason" (2 wds.) |
| 67% | HENRYFONDA | 10 | "On Golden Pond" actor who played the title role in 32-Across: 2 wds. |
| 67% | TOMELLIS | 8 | Actor who plays the titular role in the fantasy series "Lucifer": 2 wds. |
| 66% | CRAIGTNELSON | 12 | "Parenthood" actor who plays the title role on 60-Across (3 wds.) |
| 65% | KENNEDYMCMANN | 13 | Actress who plays the title role on "Nancy Drew": 2 wds. |
| 65% | EMMANUELLEWIS | 13 | Actor who played the title character on "Webster": 2 wds. |
| 64% | MATTHEWRHYS | 11 | "The Americans" actor who plays the title role in HBO's "Perry Mason": 2 wds. |
| 64% | GINARODRIGUEZ | 13 | Actress who plays the title role on 15-Across: 2 wds. |
| 63% | EDDIEMURPHY | 11 | "Coming to America" actor who played the title role in 1998's "Dr. Dolittle": 2 wds. |
| 63% | TONYTODD | 8 | "Final Destination" actor who plays the title role in 16-Across: 2 wds. |
| 63% | BOBODENKIRK | 11 | "Breaking Bad" actor who plays the lead role on 33-Across: 2 wds. |
| 63% | EWANMCGREGOR | 12 | "Beauty and the Beast" actor who plays the title role in the new movie "Christopher Robin": 2 wds. |
| 62% | IANMCSHANE | 10 | The actor who plays Mr. Wednesday on the TV series "American Gods": 2 wds. |
| 62% | MARKWILLIAMS | 12 | "Harry Potter" actor who plays the title crime-solving priest on the British TV series "Father Brown" (2 wds.) |
| 62% | DENNISQUAID | 11 | "Flight of the Phoenix" actor who plays the title role in 16-Across: 2 wds. |
| 62% | ALAN | 4 | Actor Ritchson who plays the title role on "Reacher" |
| 61% | PEDROPASCAL | 11 | "Narcos" actor who plays the title character on "The Mandalorian" (2 wds.) |
| 60% | LIEVSCHREIBER | 13 | "Spotlight" actor who has been nominated for three Emmys for playing the title role on 43-Across: 2 wds. |
| 60% | ELBA | 4 | Actor who played the title role on “Luther” |
| 60% | KEANUREEVES | 11 | "The Matrix Resurrections" actor who plays the title role in "John Wick: Chapter 4" (2 wds.) |
| 60% | TARONEGERTON | 12 | "Rocketman" actor who plays the title role in the 2018 film "Robin Hood" (2 wds.) |
| 60% | RUSSELLCROWE | 12 | "Gladiator" actor who plays the title role in the 2010 film "Robin Hood" (2 wds.) |
| 60% | MICHAELKEATON | 13 | "Mr. Mom" actor who played the title role in 40-Across (2 wds.) |
| 60% | DONJOHNSON | 10 | "Miami Vice" actor who played the title character on 40-Across (2 wds.) |
| 60% | MORRISCHESTNUT | 14 | Actor who plays the title character of 47-Across in a CBS series that premiered in January: 2 wds. |
| 60% | DEREKJACOBI | 11 | "The King's Speech" actor who plays the title role in the film "Cyrano de Bergerac" (2 wds.) |